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Neuroprotection

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of 1-EBIO | K+ channel activator | CAS 10045-45-1
    $40.00
    1-EBIO (10045-45-1) is a direct activator of small-conductance Ca2+-activated K+ channels (SK) which dose-dependently relaxes rat mesenteric vessels.1  Reverses ischemia-induced cognitive impairment2 and displays...

  • Focus Biomolecules cell signaling supplier, chemical structure of 3-Methyladenine | Autophagosome inhibitor | CAS 5142-23-4
    $30.00
    3-Methyladenine (5142-23-4) inhibits autophagy by blocking autophagosome formation via inhibition of type III phosphatidylinositol 3-kinases (PI-3K)1,2. Protects 1321N1 astrocytoma cells against pyocyanin and...

  • Allopregnanolone | GABA-A positive allosteric modulator
    $70.00
    Allopregnanolone (516-54-1) is an endogenous neurosteroid which acts as a positive allosteric modulator of GABAA receptors.1,2 Recently FDA approved (Brexanolone) for postpartum depression.3 Inhibits TLR4 receptor activation...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Apomorphine HCl | Dopamine agonist | CAS 41372-20-7
    $40.00
    Apomorphine (41372-20-7) is an archetypal dopamine pan-receptor agonist. Displays anti-Parkinsons activity in vivo.1 Protects against MPTP-induced neurotoxicity in a mouse model.2 In clinical use for Parkinson’s...

  • Bakuchiol | Antioxidant
    $0.00
    Bakuchiol (10309-37-2) is a natural terpenoid antioxidant.1 Inhibits oxidative stress-induced decrease in mitochondrial membrane potential and associated release of pro-apoptotic factors.2 Protects against acute lung injury...

  • Focus Biomolecules cell signaling supplier, chemical structure of BML-111 | LXA agonist, antiinflammatory | CAS 78606-80-1
    $50.00
    BML-111 (78606-80-1) novel truncated analog of lipoxin A4 which retains anti-inflammatory activity.1 Inhibits LTB4-induced leukocyte chemotaxis, IC50=5 nM).1 Attenuates hemorrhagic shock-induced acute lung injury in a rat...

  • Focus Biomolecules reagent supplier, chemical structure of C-DIM 12 | Nurr1 activator; NFkB inhibitor | CAS 178946-89-9
    $55.00
    C-DIM 12 (178946-89-9) activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth.1,2 Nurr1 is a suppressor of NFkB-related neuroinflammatory genes in microglia and astrocytes and C-DIM 12 suppresses...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of CGP-37157 | MPTP inhibitor | CAS 75450-34-9
    $80.00
    CGP-37157 (75450-34-9) inhibits the mitochondrial Na+-Ca2+ exchanger (NCX) in isolated heart mitochondria, IC50=0.36 mM.1 Does not inhibit the plasmalemmal NCX.2  Also inhibits voltage-gated Ca2+ channels in intact...

  • Focus Biomolecules cell signaling supplier, chemical structure of Cinnabarinic acid | Endogenous AhR ligand | CAS 606-59-7
    $50.00
    Cinnabarinic acid (606-59-7) is a novel endogenous tryptophan metabolite which acts as an aryl hydrocarbon receptor (AHR) agonist.1 It drives IL-22 production by stimulating the differentiation of human and mouse T cells...

  • Focus Biomolecules cell signaling supplier, chemical structure Dantrolene Na | SR calcium release inhibitor | CAS 14663-23-1
    $50.00
    Dantrolene Na (14663-23-1) inhibits release of Ca2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor channels with selectivity for RYR1 and RYR3 over RYR2.1 Protects against quisqualate and NMDA-induced...

  • Focus Biomolecules reagent supplier, chemical structure of Deoxymannojirimycin HCl | Mannosidase inhibitor | CAS 73465-43-7
    $35.00
    Deoxymannojirimycin HCl (CAS 73465-43-7) is a potent and selective inhibitor of α-mannosidase I.1,2 Inhibits the conversion of high mannose to complex oligosaccharides.3 Attenuates tunicamycin-, thapsigargin- and...

  • Focus Biomolecules chemical structure of DMOG | Inhibits prolyl hydroxylase domain-containing proteins | CAS 89464-63-1
    $60.00
    DMOG (89464-63-1) inhibits PHD or prolyl hydroxylase domain-containing proteins, activating HIF1α1,2 and inhibiting JMJD2A (IC50 = 2.5 μM)3. Displays neuroprotective effects. Inhibits neuronal cell death caused by...

  • Flupirtine maleate | K+ channel activator
    $55.00
    flupirtine maleate (75507-68-5) activates KV7 potassium channels1, indirectly antagonizes NMDA receptors and modulates GABAA receptors2. Displays neuroprotective actions in a model of cerebral ischemia in mice and reduces...

  • Focus Biomolecules cell signaling supplier, chemical structure of FPS-ZM1 | RAGE receptor antagonist | CAS 945714-67-0
    $60.00
    FPS-ZM1 (945714-67-0) is a high-affinity RAGE (Receptor for Advanced Glycation End products) receptor antagonist (IC50 = 0.6 μM). It lowers levels of Aβ via binding to the V domain of RAGE and can block multiple...

  • Focus Biomolecules reagent supplier, chemical structure of Gabapentin lactam | Neuroprotective agent | CAS 64744-50-9
    $58.00
    Gabapentin lactam (CAS 64744-50-9) reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease.1 Displays neurotrophic effects, enhancing the formation of dendritic...

  • Focus Biomolecules cell signaling reagent supplier, structure of Ginkgolide B | PAF receptor antagonist | CAS 15291-77-7
    $40.00
    Ginkgolide B (15291-77-7) is a PAF receptor antagonist (Ki = 1.3 μM)1. Inhibits neutrophil degranulation and superoxide production in vitro1. Inhibits PAF-induced bronchoconstriction in a guinea pig model...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of GW-5074 | c-Raf1 inhibitor | CAS 220904-83-6
    $50.00
    GW-5074 (220904-83-6) is a potent inhibitor of cRAF1 kinase (IC50 = 9 nM). Displays 100-fold selectivity for cRAF1 over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. GW-5074 displays neuroprotective effects In...

  • Focus Biomolecules cell signaling tech supplier, Idebenone | Quinone antioxidant, free radical scavenger | CAS 58186-27-9
    $70.00
    Idebenone (58186-27-9) is an analog of coenzyme Q10 which acts as an antioxidant1. Protects mitochondrial membranes against lipid peroxidation and blocks glutamate neurotoxicity in vitro and in vivo2. Increases NGF...

  • Focus Biomolecules cell signaling reagent supplier, structure of Isradipine | L-type Ca channel blocker | CAS 75695-93-1
    $64.00
    Isradipine (75695-93-1) is an L-type calcium channel blocker. Displays antiatherosclerotic effects and improves endothelium-mediated nitric oxide-dependent vasodilation. Isradipine displays neuroprotective activity in rat...

  • KY-226 | PTP1B inhibitor
    $65.00
    KY-226 (CAS 1621673-53-7)  is a selective allosteric protein tyrosine phosphatase 1B (PTP1B) inhibitor (IC50 = 250 nM) with no activity at PPARγ.1 It significantly reduced plasma glucose, triglyceride, and A1c...

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