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Neuropsych

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure 6,7-ADTN HBr | Dopamine D1 agonist | CAS 13575-86-5
    $60.00
    6,7-ADTN HBr (13575-86-5) is a broad spectrum dopamine receptor agonist.1,2  Demonstrates a marked selectivity for the human dopamine D3 receptor.3 6,7-ADTN and psychostimulants such as cocaine and amphetamine reduce...

  • Focus Biomolecules supplier, chemical structure of ABT-418 HCl | Nicotinic acetylcholine receptor agonist | CAS 147388-83-8
    $90.00
    ABT-418 (CAS 147388-83-8) is an agonist at neuronal nicotinic acetylcholine receptors displaying the highest potency at α4β2 and α2β2 subtypes (EC50= approximately 6 and 11 μM, respectively).1...

  • Allopregnanolone | GABA-A positive allosteric modulator
    $70.00
    Allopregnanolone (516-54-1) is an endogenous neurosteroid which acts as a positive allosteric modulator of GABAA receptors.1,2 Recently FDA approved (Brexanolone) for postpartum depression.3 Inhibits TLR4 receptor activation...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of ANA-12 | TrkB antagonist | CAS 219766-25-3
    $75.00
    ANA-12 (219755-25-3) is a TrkB receptor antagonist. Binds to two distinct receptor sites preventing activation by BDNF non-competitively, IC50 = 45.6 nM and 41.1 μM for the high and low affinity sites respectively...

  • Focus Biomolecules supplier, chemical structure of Aripiprazole | Dopamine receptor partial agonist | CAS 129722-2-9
    $40.00
    Aripiprazole (129722-2-9) is a clinically useful neuroleptic and antipsychotic agent.1 Dopamine D2 receptor antagonist and autoreceptor agonist.2 Improves symptoms of psychosis associated with Alzheimer's disease...

  • Citalopram HBr | Serotonin uptake inhibitor
    $52.00
    Citalopram (59729-32-7) is a potent and selective serotonin uptake inhibitor (SSRI) Ki=5.4 nM. Has no effect on norepinephrine or dopamine uptake.1 Displays cardioprotective effects in part by reducing expression of...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Clozapine | Dopamine D2/D4 antagonist | CAS 5786-21-0
    $30.00
    Clozapine (5786-21-0) is a dopamine D4 and D2 receptor antagonist. High affinity for the cloned rat dopamine D4 receptor (Ki < 20 nM).1 Atypical neuroleptic agent.2 Antagonist at 5HT2A, 5HT2C, 5HT3, 5HT6 and 5HT7...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of EPPTB | TAAR1 antagonist | CAS 1110781-88-8
    $75.00
    EPPTB (1110781-88-8) is a novel selective trace amine associated receptor 1 (TAAR1) antagonist (IC50=28 nM at mouse TAAR1).1,2 A useful tool for probing the physiologic role of TAAR1.3-6 References/Citations1) Bradaia et al...

  • Focus Biomolecules cell signaling supplier, chemical structure of Erucamide | Antidepressant/Anti-anxiety | CAS 112-84-5
    $25.00
    Erucamide (112-84-5) is an endogenous fatty acid amide.  It was able to ameliorate depression and anxiety-like behaviors in several mouse models.  Significantly lowered levels of circulating adrenocorticotrophic...

  • Fluoxetine HCl | Serotonin reuptake inhibitor
    $50.00
    Fluoxetine HCl (56296-78-7) is a selective serotonin reuptake inhibitor (SSRI) with high selectivity for the serotonin transporter (Kd=0.81 nM) over the norepinephrine (Kd=240 nM) and dopamine (Kd=3.6 mM) transporters.1 A...

  • Focus Biomolecules cell signaling supplier, chemical structure of FSC-231 | PICK1 PDZ domain inhibitor | CAS 1215849-96-9
    $60.00
    FSC-231 is the first small-molecule inhibitor of the PDZ domain in protein interacting with C kinase 1 (PICK1). Binds to PICK1 PDZ domain with affinity similar to that of the endogenous peptide ligands (Ki~10.1 µM)...

  • Focus Biomolecules supplier, chemical structure of GBR-12909 2HCl | Dopamine reuptake inhibitor | CAS 67469-78-7
    $60.00
    GBR-12909 2HCl (67469-78-7) is a potent and selective inhibitor of dopamine reuptake (Ki = 1 nM) with greater than 100 fold selectivity over serotonin and noradrenaline.1 GBR-12909 2HCl also acts as a potent sigma...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of ML-297 | GIRK inhibitor | CAS 1443246-62-5
    $70.00
    ML-297 (1443246-62-5) is a selective GIRK 1/2 (Kir3.1/3.2) channel activator, IC50 = 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively. Has no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels.1,2...

  • Focus Biomolecules cell signaling supplier, chemical structure Norquetiapine 2HCl | Quetiapine metabolite | CAS 111974-74-4
    $60.00
    Norquetiapine 2HCl (111974-74-4) is a pharmacologically active metabolite of quetiapine (Seroquel).1  Exhibits distinct pharmacological activity from quetiapine and plays an important role in its antidepressant activity...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Perphenazine | Antipsychotic agent | CAS 58-39-9
    $25.00
    Perphenazine (58-39-9) is a clinically useful typical antipsychotic drug. The therapeutic mode of action is not well understood but it binds to a wide variety of receptors including serotonin, histamine, dopamine, and...

  • Pridopidine | Sigma-1 ligand Neuroprotectant/Neurorestorative
    $80.00
    Pridopidine is being studied as a potential treatment for Huntington’s disease, Parkinson’s disease, and schizophrenia based on its locomotor stabilizing and antipsychotic-like effects.1,2 It was, unusually, able...

  • Focus Biomolecules supplier, chemical structure of Quetiapine hemifumarate | Atypical antipsychotic agent | CAS 111974-72-2
    $30.00
    Quetiapine hemifumarate (111974-72-2) is an atypical antipsychotic agent. Antagonist at serotonin (5-HT2) and dopamine (D2) receptors, IC50s=148 and 329 nM respectively.2 Reverses depressive-like behavior and reduces DNA...

  • Siramesine | Selective sigma-2 agonist
    $70.00
    Siramesine (Lu 28-179, 147817-50-3) is a σ2 selective agonist (IC50’s: σ1 = 17nM, σ2 = 0.2nM).1 It produced non-sedating potent and long-last anxiolytic effects in rodents.2 Siramesine induced...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Theanine | GABA agonist | CAS 3081-61-6
    $25.00
    L-Theanine (3081-61-6) is a naturally occurring amino acid found in tea leaves. It is able to cross the blood brain barrier and has been shown to have psychoactive effects1 including cognition improvement, reduction of...

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