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Neurotransmitters

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  • Focus Biomolecules supplier, chemical structure of (±) Tranylcypromine hemisulfate | Demethylase inhibitor | CAS 13492-01-8
    (±) Tranylcypromine hemisulfate | Demethylase inhibitor
    $40.00
    Tranylcypromine (13492-01-8) is an irreversible and non-selective monoamine oxidase inhibitor.1,2 It has been shown to inhibit the histone demethylase BHC110/LSD1.3,4 References/Citations1) Knoll et al. (1980), Monoamine...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of 1400W | iNOS inhibitor | CAS 214358-33-5
    1400W | iNOS inhibitor
    $40.00
    1400W (214358-33-5) is a potent, tight-binding, slow inhibitor of inducible nitric oxide synthase (iNOS). Highly selective for iNOS3 (Ki = 7 nM) over nNOS or eNOS (Ki's of 2 μM and 50 μM respectively).1 1400W is cell...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure 6,7-ADTN HBr | Dopamine D1 agonist | CAS 13575-86-5
    6,7-ADTN HBr | Dopamine D1 agonist
    $60.00
    6,7-ADTN HBr (13575-86-5) is a broad spectrum dopamine receptor agonist.1,2  Demonstrates a marked selectivity for the human dopamine D3 receptor.3 6,7-ADTN and psychostimulants such as cocaine and amphetamine reduce...

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  • 9-Hydroxyrisperidone | Risperidone metabolite
    9-Hydroxyrisperidone | Risperidone metabolite
    $30.00
    9-Hydroxyrisperidone (144598-75-4) is a pharmacologically active metabolite of risperidone, an atypical antipsychotic agent.1 Displays high affinity for serotonin 5-HT2A receptors as well as dopamine D2 receptors...

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  • Focus Biomolecules supplier, chemical structure of AM-404 | Anandamide transport inhibitor | CAS 198022-70-7
    AM-404 | Anandamide transport inhibitor
    $40.00
    AM-404 (198022-70-7) inhibits anandamide transport (IC50 = 1 μM) without inhibiting anandamide amidase or activating cannabinoid receptors.1,2 Vanilloid receptors are activated by AM-404.3 Active in vivo...

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  • Focus Biomolecules cell signaling reagent supplier, structure of Amlodipine | L-type Ca channel blocker | CAS 88150-42-9
    Amlodipine | L-type Ca channel blocker
    $30.00
    Amlodipine (88150-42-9) is an anti-hypertensive L-type calcium channel blocker, which also benefits the cardiovascular system by stimulating nitric oxide synthase, inhibiting angiotension-induced oxidative stress and...

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  • Focus Biomolecules supplier, chemical structure of Anandamide | Endogenous cannabinoid | CAS 94421-68-8
    Anandamide | Endogenous cannabinoid
    $35.00
    Anandamide (94421-68-8) is an endogenous cannabinoid receptor agonist.1-3 Ki=89 nM for CB1 and 371 nM for CB2 receptors. References/Citations1) Devane et al. (1992), Isolation and structure of a brain constituent that binds...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure Apomorphine HCl | Dopamine agonist | CAS 41372-20-7
    Apomorphine HCl | Dopamine agonist
    $40.00
    Apomorphine (41372-20-7) is an archetypal dopamine pan-receptor agonist. Displays anti-Parkinsons activity in vivo.1 Protects against MPTP-induced neurotoxicity in a mouse model.2 In clinical use for Parkinson’s...

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  • Focus Biomolecules supplier, chemical structure of Aripiprazole | Dopamine receptor partial agonist | CAS 129722-2-9
    Aripiprazole | Dopamine receptor partial agonist
    $40.00
    Aripiprazole (129722-2-9) is a clinically useful neuroleptic and antipsychotic agent.1 Dopamine D2 receptor antagonist and autoreceptor agonist.2 Improves symptoms of psychosis associated with Alzheimer's disease...

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  • Focus Biomolecules cell signaling reagent supplier, structure of Astemizole | hERG channel blocker | CAS 68844-77-9
    Astemizole | hERG channel blocker
    $30.00
    Astemizole (68844-77-9) is an antagonist at the histamine H1 receptor. References/Citations1) Richards et al. (1984), Astemizole. A review of its pharmacodynamic properties and therapeutic efficacy; Drugs, 28 38 2) Laduron...

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  • Focus Biomolecules supplier, chemical structure of Benztropine mesylate | Induces remyelination of neurons | CAS 132-17-2
    Benztropine mesylate | Induces remyelination of neurons
    $38.00
    Benztropine mesylate (132-17-2) is a centrally acting M1 muscarinic acetylcholine receptor antagonist (Ki=0.59 nM, rat).1 Also inhibits the dopamine transporter (Ki=160 nM).2 Benztropine mesylate enhances remyelination and...

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  • Focus Biomolecules reagent supplier, chemical structure of Bithionol | Glutamate dehydrogenase inhibitor | CAS 97-18-7
    Bithionol | Glutamate dehydrogenase inhibitor
    $20.00
    Bithionol (97-18-7) is an antihelmintic drug with bacteriostatic and fungicidal properties. Bithionol has also been found to be an inhibitor of glutamate dehydrogenase1,2 (IC50 = 4.8 μM bovine GDH1)...

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  • Focus Biomolecules cell signaling reagent supplier, Bromocriptine mesylate | Dopamine D2/D3 agonist | CAS 22260-51-1
    Bromocriptine mesylate | Dopamine D2/D3 agonist
    $65.00
    Bromcriptine mesylate (22260-51-1) is a dopamine D2 receptor agonist. Inhibits prolactin production3. Decreases cocaine self-administration in the rat4. Active in vivo. References/Citations1) Nilsson and Hokfelt (1978),...

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  • Focus Biomolecules cell signaling supplier, chemical structure of Cinnabarinic acid | Endogenous AhR ligand | CAS 606-59-7
    Cinnabarinic acid | Endogenous AhR ligand
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    Cinnabarinic acid (606-59-7) is a novel endogenous tryptophan metabolite which acts as an aryl hydrocarbon receptor (AHR) agonist.1 It drives IL-22 production by stimulating the differentiation of human and mouse T cells...

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  • Citalopram HBr | Serotonin uptake inhibitor
    Citalopram HBr | Serotonin uptake inhibitor
    $52.00
    Citalopram (59729-32-7) is a potent and selective serotonin uptake inhibitor (SSRI) Ki=5.4 nM. Has no effect on norepinephrine or dopamine uptake.1 Displays cardioprotective effects in part by reducing expression of...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure Clozapine | Dopamine D2/D4 antagonist | CAS 5786-21-0
    Clozapine | Dopamine D2/D4 antagonist
    $30.00
    Clozapine (5786-21-0) is a dopamine D4 and D2 receptor antagonist. High affinity for the cloned rat dopamine D4 receptor (Ki < 20 nM).1 Atypical neuroleptic agent.2 Antagonist at 5HT2A, 5HT2C, 5HT3, 5HT6 and 5HT7...

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  • Focus Biomolecules reagent supplier, chemical structure Cycloserine, D(+) | NMDA, glycine site partial agonist | CAS 68-41-7
    Cycloserine, D(+) | NMDA, glycine site partial agonist
    $60.00
    D-Cycloserine (68-41-7) is a partial agonist at the glycine modulatory site of NMDA glutamatergic receptors.1 Blocks kainate-induced seizures2 and displays anticonvulsant effects3 in rat models. D-Cycloserine facilitates...

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  • Focus Biomolecules supplier, chemical structure Cyclothiazide | AMPA receptor positive allosteric modulator | CAS 2259-96-3
    Cyclothiazide | AMPA receptor positive allosteric modulator
    $50.00
    Cyclothiazide (2259-96-3) is a positive allosteric modulator of AMPA receptors acting at a site distinct from that of 2,3-benzodiazepines.1,2 Clinically useful diuretic and antihypertensive agent.3 Induces robust...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of DETA NONOate | NO Donor | CAS 146724-94-9
    DETA NONOate | NO Donor
    $35.00
    DETA NONOate (146724-94-9) is a nitric oxide donor and dissociates to the free amine and NO in a pH dependent manner. The half-life of DETA NONOate in 0.1 M phosphate buffer at pH 7.4 is 20 hours at 37°C, or 56 hours at...

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  • Focus Biomolecules supplier, chemical structure of Efaroxan HCl | alpha 2 adrenergic antagonist | CAS 89197-00-2
    Efaroxan HCl | alpha 2 adrenergic antagonist
    $80.00
    Efaroxan HCl (89197-00-2) is a selective α2-adrenergic receptor antagonist1 (selectivity ratio of α2/α1 = 724)4 and imidazoline receptor antagonist2. Induces release of insulin in the rat insulinoma cell...

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