my account
Login
  Loading... Please wait...

Neurovascular

Sort by
  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Argatroban | Thrombin inhibitor | CAS 74863-84-6
    $56.00
    Argatroban (74863-84-6) is a potent and selective inhibitor of thrombin (Ki = 19 nM)1. Prevents platelet-rich arterial thrombosis in a rabbit model2. Ameliorates early brain injury and improves neurological outcomes after...

  • Focus Biomolecules supplier, chemical structure of Ebselen | Glutathione peroxidase mimic | CAS 60940-34-3
    $28.00
    Ebselen (60940-34-3) is a novel nontoxic selenium-containing multifunctional antioxidant and anti-inflammatory agent.1 Displays protective effects in reperfusion injury and stroke.2 Ebselen is an excellent...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of GPI-16552 | PARG inhibitor | CAS 443794-40-9
    $60.00
    GPI-16552 (443794-40-9) is a novel potent inhibitor of poly(ADP-ribose) glycohydrolase (PARG), IC50=1.7 μM1. Pre or post ischemia treatment (40 mg/kg) with GPI-16552 reduces brain infarct volumes in a rat model of...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of HC-067047 | TRPV4 blocker | CAS 883031-03-6
    $58.00
    HC-067047 (883031-03-6) is a potent reversible and selective TRPV4 antagonist. Active at mouse, human and rat TRPV4, IC50 = 17, 48 and 133 nM respectively. Also inhibits the endogenous TRPV4-mediated response to 4α-PDH...

  • Focus Biomolecules cell signaling supplier, chemical structure of Ibudilast | Neuroinflammation inhibitor | CAS 50847-11-5
    $40.00
    Ibudilast (CAS 50847-11-5) is a phosphodiesterase inhibitor with some selectivity for PDE4 and 5. (IC50s= 53, 35, 48, 12 and 10 μM for PDE 1a, 2, 3, 4 and 5 respectively1). Acts as a cerebral vasodilator by selectively...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of MCI-186 | Antioxidant-nonphenolic | CAS 89-25-8
    $35.00
    MCI-186 (89-25-8), also known as edaravone,  is an antioxidant free radical scavenger used as a neuroprotective agent following acute brain ischemia and subsequent cerebral infarction.1,2 MCI-186 also protects against...

  • Focus Biomolecules cell signaling reagent supplier, structure of Sodium Valproate | HDAC inhibitor | CAS 1069-66-5
    $26.00
    Sodium Valproate (1069-66-5) is a histone deacetylase inhibitor (IC50 = 400µM).1 Demonstrates neuroprotective, anticancer, and anti-inflammatory activity.2  Inhibits Aβ production, reduced neuritic plaque...

  • Focus Biomolecules reagent supplier, chemical structure of Ozagrel HCl | Thromboxane synthase inhibitor | CAS 78712-43-3
    $48.00
    Ozagrel HCl (78712-43-3) is a potent and selective inhibitor of thromboxane (TXA2) synthetase (IC50 = 4 nM)1. Does not inhibit prostacyclin (PGI2) synthase, cyclooxygenase or PGE2 isomerase (IC50 > 1 mM)1. Inhibits...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Pifithrin alpha | p53 inhibitor | CAS 63208-82-2
    $50.00
    Pifithrin α (63208-82-2) is a reversible inhibitor of p53-mediated transcription and p53-dependent apoptosis. Enhances survival after genotoxic stress and protects against chemotherapeutic side-effects in mice.1,2...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of TGN-020 | Aquaporin 4 blocker | CAS 51987-99-6
    $75.00
    TGN-020 (51987-99-6) is an aquaporin 4 channel blocker, IC50 = 3.1 μM.1 Reduces ischemic cerebral edema in a mouse model of focal cerebral ischemia using MRI.2 TGN-020 increases regional cerebral blood flow as...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Vinpocetine | PDE1 inhibitor | CAS 42971-09-5
    $30.00
    Vinpocetine (42971-09-5) is a phosphodiesterase PDE1 inhibitor (IC50=21 μM).1 Also blocks voltage-gated Na+ channels, IC50=44.2 μM (potency similar to phenytoin), a mechanism which may contribute to its neuroprotective...

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus