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  • Focus Biomolecules cell signaling reagent supplier, Bromocriptine mesylate | Dopamine D2/D3 agonist | CAS 22260-51-1
    Bromcriptine mesylate (22260-51-1) is a dopamine D2 receptor agonist. Inhibits prolactin production3. Decreases cocaine self-administration in the rat4. Active in vivo. References/Citations1) Nilsson and Hokfelt (1978),...

  • Clozapine-N-oxide | DREADD agonist
    Clozapine-N-oxide (34233-69-7) is a clozapine metabolite1 which is pharmacologically inert2. Agonist at human muscarinic designer receptors known as DREADDs, (designer receptors exclusively activated by designer drug).2...

  • Deltamethrin | Calcineurin inhibitor; displays neurotrophic activity
    Deltamethrin (52918-63-5) is reported to be an inhibitor of calcineurin (PP2B), IC50~100 pM1 but this activity has been disputed2. Markedly enhances the expression of BDNF in cultured rat cortical neurons and displays...

  • FSC-231 | PICK1 PDZ domain inhibitor
    FSC-231 is the first small-molecule inhibitor of the PDZ domain in protein interacting with C kinase 1 (PICK1). Binds to PICK1 PDZ domain with affinity similar to that of the endogenous peptide ligands (Ki~10.1 µM)...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of ICA-11381 | Kv7.2/7.3 activator | CAS 325457-99-6
    ICA-110381 (325457-99-6) is a KCNQ2/Q3 (Kv7.2/7.3) activator, EC50=0.38 μM (KCNQ1 IC50=15 μM)1. KCNQ3/Q5 heterodimers are not affected2. Potently dampens neuronal excitability and displays anticonvulsant activity in...

  • Linamarin | Neurotoxic cyanogenic glycoside
    Linamarin (554-35-8) is a cyanogenic glycoside defense compound produced by plants and insects.1 Found in cassava.2 Displays neurotoxic effects in rats.2 Induces memory and cognition deficits in rodents...

  • M-1 | 219315-22-7 | Structure | Supplier
    Enhances mitochondrial fusion without interfering with endoplasmic reticulum (ER) and lysosome morphology.1 M-1 protects cells from mitochondrial fragmentation-associated cell death.2 Promotion of mitochondrial fusion has...

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