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PhysioProcesses

Pain

Pain is “an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage” according to the International Association for the Study of Pain. It may be acute or chronic in nature and is an important component of quality of life. Pain research involves multiple areas, including opioid and cannabinoid signaling, inflammation, nitric oxide, TRP and other ion channels, and many others.

Calcium channels

BAY-1797 | P2X4 antagonist

CAS:
2055602-83-8
Catalog Number:
10-3980
Activity:
P2X4 antagonist
Chemical Names:
N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide
Molecular Weight:
416.88
Molecular Formula:
C20H17ClN2O4S
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Pale brown solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

A-438079 HCl | P2X7 antagonist

CAS:
899431-18-6
Catalog Number:
10-4063
Activity:
P2X7 antagonist
Chemical Names:
3-[5-(2,3-Dichlorophenyl)tetrazol-1-ylmethyl]pyridine hydrochloride
Molecular Weight:
342.61
Molecular Formula:
C13H9Cl2N5·HCl
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White to off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

TTA-P2 | Potent and selective T-type calcium channel antagonist

CAS:
918430-49-6
Catalog Number:
10-3993
Activity:
Selective T-type calcium channel antagonist
Chemical Names:
(±)-3,5-Dichloro-N-[[1-[(2,2-dimethyloxan-4-yl)methyl]-4-fluoropiperidin-4-yl]methyl]benzamide
Molecular Weight:
431.37
Molecular Formula:
C21H29Cl2FN2O2
Solubility:
Soluble in DMSO (10 mg/ml)
Physical Properties:
Tan solid
Purity:
>97% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Cannabinoid

WIN-55212-2 mesylate | Cannabinoid CB1/CB2 agonist

CAS:
131543-23-2
Catalog Number:
10-2002
Activity:
Cannabinoid CB1/CB2 agonist
Chemical Name:
(R)-(+)-[2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone mesylate
Molecular Weight:
522.62
Molecular Formula:
C27H26N2O3 CH3SO3H
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

AM-404 | Anandamide transport inhibitor

CAS:
198022-70-7
Catalog Number:
10-2008
Activity:
Anandamide transport inhibitor
Chemical Name:
N-(4-Hydroxyphenyl)arachidonamide
Molecular Weight:
395.58
Molecular Formula:
C26H37NO2
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Compound is subject to oxidation, store under inert gas to protect from exposure to air. Solutions in DMSO or ethanol may be stored under nitrogen or argon at -20° for up to 3 months.
Shipping Code:
Blue Ice

Anandamide | Endogenous cannabinoid

CAS:
94421-68-8
Catalog Number:
10-2009
Activity:
Endogenous cannabinoid
Alternate Names:
Arachidonoylethanolamide; AEA
Chemical Name:
N-(2-Hydroxyethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Molecular Weight:
347.54
Molecular Formula:
C22H27NO2
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 50 mg/ml).
Physical Properties:
Colorless oil
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-80°C
Stability:
Stable for 1 year from date of purchase as supplied. Subject to oxidation – protect from air. Solutions in degassed DMSO or ethanol may be stored under nitrogen or argon at -80°C for up to 1 month.
Shipping Code:
Blue Ice

COX

Rofecoxib | Selective COX-2 inhibitor

CAS:
162011-90-7
Catalog Number:
10-2440
Activity:
Selective COX-2 inhibitor
Alternate Names:
MK-966
Chemical Name:
4-[4-(Methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone
Molecular Weight:
314.36
Molecular Formula:
C17H14O4S
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Sulindac Sulfide | NFkappaB inhibitor

CAS:
32004-67-4
Catalog Number:
10-2156
Activity:
NFkappaB inhibitor
Chemical Name:
(Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid
Molecular Weight:
340.42
Molecular Formula:
C20H17FO2S
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Celecoxib | COX II inhibitor

CAS:
169590-42-5
Catalog Number:
10-2124
Activity:
COX II inhibitor
Alternate Names:
SC-58635
Chemical Name:
4-(5-(p-Tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide
Molecular Weight:
381.38
Molecular Formula:
C17H14F3N3O2S
Solubility:
Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 100 mg/ml).
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

GABA

Tiagabine hydrochloride | GABA transporter 1 (GAT1) inhibitor

CAS:
145821-59-6
Catalog Number:
10-4384
Activity:
GABA transporter 1 (GAT1) inhibitor
Chemical Name:
(3R)-1-[4,4-Bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid
Alternate Name:
NO-328
Molecular Weight:
412.00
Molecular Formula:
C20H25NO2S2 • HCl
Solubility:
Soluble in DMSO (up to at least 25 mg/ml), in Ethanol (up to at least 25 mg/ml) or in Water (up to at least 30 mg/ml)
Physical Properties:
Off-white or beige solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol, or distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT

Nitric oxide

TRIM | Nitric oxide synthase inhibitor

CAS:
25371-96-4
Catalog Number:
10-2699
Activity:
Nitric oxide synthase inhibitor
Chemical Name:
1-(2-Trifluoromethylphenyl)imidazole
Molecular Weight:
212.18
Molecular Formula:
C107F3N2
Solubility:
Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Prostanoid receptors

Grapiprant | EP4 Receptor antagonist

CAS:
415903-37-6
Catalog Number:
10-4006
Activity:
EP4 Receptor antagonist
Chemical Name:
1—[2-[4-(2-Ethyl-4,6-dimethylimidazo[4,5-c]pyridine-1-yl)phenyl]ethyl]-3-(4-methylphenyl)sulfonylurea
Alternate Names:
CJ-023423; ARY-007
Molecular Weight:
491.61
Molecular Formula:
C26H29N5O3S
Solubility:
Soluble in DMSO (up to at least 10 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

SC-51089 | Prostaglandin E2 (EP1) antagonist

CAS:
146033-02-5
Catalog Number:
10-1135
Activity:
PGE2 (EP1 receptor) antagonist
Chemical Names:
8-Chlorodibenz(Z)[b,f]oxazepine-10(11H)-carboxylic acid 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide hydrochloride
Molecular Weight:
459.34
Molecular Formula:
C22H19ClN4O3·HCl
Solubility:
Soluble in DMSO (25 mg/ml) or water (25 mg/mL)
Physical Properties:
White solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Sodium channels

ICA-121431 | Selective Sodium channel blocker

CAS:
313254-51-2
Catalog Number:
10-4085
Activity:
Selective Nav1.1/1.3 inhibitor
Chemical Names:
2,2-Diphenyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]acetamide
Molecular Weight:
449.54
Molecular Formula:
C23H19N3O3S2
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white to beige solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

BAY-1797 | P2X4 antagonist

CAS:
2055602-83-8
Catalog Number:
10-3980
Activity:
P2X4 antagonist
Chemical Names:
N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide
Molecular Weight:
416.88
Molecular Formula:
C20H17ClN2O4S
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Pale brown solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

A-438079 HCl | P2X7 antagonist

CAS:
899431-18-6
Catalog Number:
10-4063
Activity:
P2X7 antagonist
Chemical Names:
3-[5-(2,3-Dichlorophenyl)tetrazol-1-ylmethyl]pyridine hydrochloride
Molecular Weight:
342.61
Molecular Formula:
C13H9Cl2N5·HCl
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White to off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

TRP channels

Resiniferatoxin | TRPV1 activator

CAS:
57444-62-9
Catalog Number:
10-2103
Activity:
TRPV1 activator
Chemical Names:
RTX
Molecular Weight:
628.71
Molecular Formula:
C37H40O9
Solubility:
Soluble in DMSO (65 mg/ml) or ethanol (30 mg/mL)
Physical Properties:
Off-white waxy solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Icilin | TRPM8 activator

CAS:
36945-98-9
Catalog Number:
10-4380
Activity:
TRPM8 activator
Alternate Names:
AG 3-5
Chemical Name:
3,6-Dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-1H-pyrimidin-2-one
Molecular Weight:
311.29
Molecular Formula:
C16H13N3O4
Solubility:
Soluble in DMSO (up to 25 mg/ml),
Physical Properties:
Yellow solid
Purity:
>98% by TLC
NMR (conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

HC-067047 | TRPV4 blocker

CAS:
883031-03-6
Catalog Number:
10-1480
Activity:
TRPV4 blocker
Chemical Name:
2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
Molecular Weight:
471.51
Molecular Formula:
C26H28F3N3O2
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Other Pain

YL-365 | GPR34 antagonist

YL-365 is a potent (IC50 = 17 nM) and selective antagonist of GPR34, a GPCR for lysophosphatidylserine.1 GPR34 is highly expressed in various immune cells and