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  • A-803467 | 944261-79-4 | Structure | Supplier
    A-803467 (944261-79-4) is a potent, selective inhibitor of the TTX-resistant voltage-gated sodium channel Nav1.8. Nav1.8 is preferentially expressed in sensory neurons, and inhibition attenuates both inflammatory and...

  • A-967079 | 1170613-55-4 | Structure | Supplier
    A-967079 (1170613-55-4) is a TRPA1 antagonist. Active in rat models.1 Cell permeable References/Citations1) McGaraughty et al. (2010), TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in...

  • AM-404 | 198022-70-7 | Structure | Supplier
    AM-404 (198022-70-7) inhibits anandamide transport (IC50 = 1 μM) without inhibiting anandamide amidase or activating cannabinoid receptors.1,2 Vanilloid receptors are activated by AM-404.3 Active in vivo...

  • Ambroxol HCl | Free radical scavenger
    Ambroxol HCl (18683-91-5) is a radical scavenger with anti-inflammatory activity. Blocks the generation of reactive oxygen species by bronchoalveolar lavage cells, inhibits doxorubicin-induced lipid peroxidation (70 mg/kg in...

  • Anandamide | Endogenous cannabinoid
    Anandamide (94421-68-8) is an endogenous cannabinoid receptor agonist.1-3 Ki=89 nM for CB1 and 371 nM for CB2 receptors. References/Citations1) Devane et al. (1992), Isolation and structure of a brain constituent that binds...

  • AP-18 | 552244-94-7 | Structure | Supplier
    AP-18 (55224-94-7) is a selective TRPA1 (transient receptor potential A1) channel blocker (IC50 = 3.1 and 4.5 μM at human and mouse TRPA1 respectively). References/Citations1) Petrus et al. (2007) A role of TRPA1 in...

  • BCTC | 393514-24-4 | Structure | Supplier
    BCTC (393514-24-4) is a vanilloid receptor I (TRPV1) antagonist, IC50 = 35 nM for capsaicin-induced and 6 nM for acid-induced TRPV1 activation. Displays analgesic activity in rat models of neuropathic pain. BCTC is orally...

  • BD1047 dihydrobromide | Selective sigma-2 antagonist
    BD1047 (138356-21-5) is a potent and selective sigma-1 antagonist (IC50’s:  σ1 = 0.93nM, σ2 = 47nM). .1 Pretreatment of mice with BD1047 reduced convulsions, lethality, and locomotor activity induced...

  • BD1063 dihydrochloride | Selective sigma-1 antagonist
    BD1063 (206996-13-6) is potent and selective sigma-1 antagonist (IC50’s: σ1 = 9nM, σ2 = 449nM).1 BD1063 abolished mechanical and thermal hyperalgesia in mice with carrageenan-induced acute inflammation by...

  • Capsaicin (natural) | TRPV1 agonist
    Capsaicin (404-86-4) is a vanilloid agonist known to activate the transient receptor potential channel vanilloid subfamily member 1 (TRPV1)1,2 and to possess analgesic3, anti-inflammatory4 and hypolocomotor effects5. SEVERE...

  • Celecoxib | COX II inhibitor
    Celecoxib (169590-42-5) is a selective inhibitor of cyclooxygenase-2 (COX-2) IC50 = 15 and 0.04 μM for COX-1 and COX-2 respectively.1 Potent and clinically useful antiinflammatory agent.2 Cancer chemopreventive...

  • Gabapentin | Neuropathic pain drug
    Gabapentin (60142-96-3) is an approved drug for treatment of various types of neuropathic pain and some forms of epilepsy.  The mechanism of action of gabapentin is not well understood. Despite being a structural mimic...

  • HC-030031 | 349085-38-7 | Structure | Supplier
    HC-030031 (349085-38-7) inhibits TRPA1 channel. References/Citations1) McNamara et al. (2007), TRPA1 mediates formalin-induced pain; Proc. Natl. Acad. Sci., 104...

  • HC-067047 | 883031-03-6 | Structure | Supplier
    HC-067047 (883031-03-6) is a potent reversible and selective TRPV4 antagonist. Active at mouse, human and rat TRPV4, IC50 = 17, 48 and 133 nM respectively. Also inhibits the endogenous TRPV4-mediated response to 4α-PDH...

  • Icilin | TRPM8 inhibitor
    Icilin (36945-98-9) is an agonist of cold-sensitive TRP channels with 2.5-fold greater efficacy and 200-fold greater potency than menthol (EC50 = 0.36 μM for CRM1, rat orthologue of TRPM8).1 Agonist at TRPM8 (EC50 = 0.2...

  • JNJ-1661010 | 681136-29-8 | Structure | Supplier
    JNJ-1661010 (681136-29-8) is a potent and selective FAAH inhibitor. Initially forms a covalent adduct with FAAH but is slowly released, IC50 = 12 nM. 100-fold selectivity for FAAH-1 over FAAH-2. Cell permeable and active in...

  • JZL-184 | 1101854-58-3 | Structure | Supplier
    JZL-184 (1101854-58-3) inhibits MAG lipase (IC50=8 nM) selectively over FAAH. Irreversible. Cell permeable. References/Citations1) Long et al. (2009), Selective blockade of 2-arachidonoylglycerol hydrolysis produces...

  • Minocycline HCl | Neuroprotective; antiapoptotic
    Minocycline HCl (13614-98-7) displays antiapoptotic, anti-inflammatory1 activity. Prevents neuropathic pain in a rat sciatic nerve injury model1. Reduces MMP-9 activity2. Attenuates disease severity in mouse models of...

  • Oxaprozin | 21256-18-8 | Structure | Supplier
    Oxaprozin (21256-18-8) is a clinically useful non-steroidal anti-inflammatory drug.1 In addition to typical NSAID COX inhibition, oxaprozin may also exert anti-inflammatory effects via inhibition of the Akt/IKK/NF-κB...

  • PBMC | Structure | Supplier
    PBMC is a potent and selective inhibitor of TRPM8 channels. PBMC inhibits both chemical and thermal activation of TRPM8.1 Reverses the menthol and cold-induced facilitation of the micturition reflex.2 PBMC...

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