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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Polygodial | TRPA1 agonist | CAS 6754-20-7
    $60.00
    Polygodial (6754-20-7) is a TRPA1 agonist (EC50=400 nM)1. A naturally occurring drimane sesquiterpene dialdehyde found in a variety of plant species including water pepper (Polygonum hydropiper). Polygodial has been used in...

  • Focus Biomolecules cell signaling tech supplier, chemical structure Rofecoxib | Selective COX-2 inhibitor | CAS 162011-90-7
    $60.00
    Rofecoxib (162011-90-7) is a potent and selective COX-2 inhibitor with 1000-fold selectivity over COX-1, IC50=26 nm vs >50 μM1. Potent nonsteroidal anti-inflammatory agent1. Rofecoxib is a clinically useful NSAID which...

  • S1RA | Selective sigma-1 antagonist
    $85.00
    S1RA (E-52862, 1265917-14-3) is a potent and selective σ1 antagonist with weak binding at σ2 (IC50 σ1 = 17nM, σ2 = 9300nM).1,2 S1RA abolished mechanical and thermal hyperalgesia in mice with...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of SB-366791 | TRPV1 blocker | CAS 472981-92-3
    $60.00
    SB-366791 (472981-92-3) is a potent (IC50 = 0.7 µM) and selective TRPV1 antagonist.1,2 Selective for TRPV1 in a panel of 47 different binding assays. References/Citations1) Gunthorpe, et al., (2004) Identiication and...

  • Focus Biomolecules cell signaling tech supplier, structure of SC-51089 | Prostaglandin E2 (EP1) antagonist | CAS 146033-02-5
    $60.00
    SC-51089 (146033-02-5) is a prostaglandin E2 (EP1 receptor) antagonist (pA2=6.5, guinea pig ileum muscle strip assay )1,4. Possesses analgesic activity in vivo (rodent ED50= 6.8 mg/kg)1,2,4. SC-51089 does not inhibit COX11...

  • Focus Biomolecules cell signaling reagent supplier, structure of SR-144528 | Cannabinoid CB2 antagonist | CAS 192703-06-3
    $100.00
    SR-144528 (192703-06-3) is a potent and selective antagonist of the cannabinoid CB2 receptor1,2. References/Citations1) Rinaldi-Carmona et al. (1998), SR-144528, the first potent and selective antagonist of the CB2...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Sulindac Sulfide | NFkB inhibitor | CAS 32004-67-4
    $50.00
    Sulindac sulfide (32004-67-4) is the active metabolite of cyclooxygenase inhibitor sulindac.1 Strongly inhibits Ras induced malignant transformation and Ras/Raf dependent transactivation.2 Sulindac sulfide induces apoptosis...

  • Focus Biomolecules cell signaling supplier, chemical structure of TRIM | Nitric oxide synthase inhibitor | CAS 25371-96-4
    $35.00
    TRIM (25371-96-4) is a potent inhibitor of neuronal and inducible nitric oxide synthases, (IC50 = 28.2 and 27.0 μM respectively). Inhibits endothelial NOS with lower potency (IC50 = 1057.5 μM1. TRIM displays...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of URB-597 | FAAH inhibitor | CAS 546141-08-6
    $35.00
    URB-597 (546141-08-6) is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor, IC50 = 3-5 nM.1 Produces cannabinoid CB1 and CB2 receptor-mediated analgesia in inflammatory pain states without causing side...

  • Focus Biomolecules supplier, chemical structure of WIN-55212-2 mesylate | Cannabinoid CB1/CB2 agonist | CAS 131543-23-2
    $70.00
    WIN-55212-2 mesylate (131543-23-2) is a high affinity cannabinoid receptor agonist (Ki = 62.3 nM for recombinant human CB1 and 3.3 nM for recombinant human CB2)1 with analgesic2 and anti-inflammatory activities. WIN-55212-2...

  • Focus Biomolecules supplier, chemical structure of Zolmitriptan | Serotonin 5HT1B/1D receptor agonist | CAS 139264-17-8
    $50.00
    Zolmitriptan (CAS 139264-17-8) is a potent and selective serotonin 5HT 1B/1D agonist (Ki=0.63 and 5.01 nM for 5HT 1D and 1B respectively.1 Displays proven efficacy for the treatment of migraine.2 Inhibits neurogenic...

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