New Products

BTB-1 | Mitotic kinesin Kif18A inhibitor

Selective, ATP-competitive and reversible inhibitor of mitotic kinesin Kif18A. Suppresses the replication of influenza A virus,

Chromomycin A3 | DNA Stain

DNA-binding agent specific for GC-rich sequences which may be used as a DNA stain. Inhibits neuronal apoptosis induced by oxidative stress and DNA damage.

Cytochalasin B | Actin filament disrupting agent

Cell permeable fungal toxin which binds to the barbed end of actin, inhibiting its polymerization. Inhibits cell division, migration and glucose transport.

Oleamide | Endogenous sleep inducing ligand

Displays agonist activity at cannabinoid CB1 receptors. Activates PPARγ. Displays neuroprotective effects and attenuates sepsis-induced intestinal injury.

WP631 | Inhibits SP-1 activated transcription

Potent inhibitor of Sp1-activated transcription. Induces caspase-dependent apoptosis in human ovarian cancer cells.

Tomentosin | Inhibitor of NFkB activation

It suppresses the production of inflammatory mediators by inhibiting NFκB activation. Induces Apoptosis in some cancer cell lines.

Dodecyl-TPP | Mitochondrial-targeted cancer stem cell inhibitor

Inhibits mitochondrial function inhibiting oxidative phosphorylation and shifting cell metabolism to glycolysis. Potently eradicates cancer stem cells selectively over normal cells.

4-MUG | beta-Glactosidase fluorogenic substrate

Versatile fluorogenic substrate for β-galactosidase1 for use in cell extracts or purified enzyme preparations.

AE 51310 | OPN4/Melanopsin antagonist

Potent antagonist of the GPCR OPN4/melanopsin. OPN4 regulates circadian rhythms, pupil functions, melatonin expression, cognition, and sleep.

BO-264 | TACC3 inhibitor

Potent inhibitor of transforming acidic coiled-coil 3 (TACC3), an important protein involved in microtubule stability and centrosome integrity.

Ipatasertib | Pan-AKT inhibitor

Selective and potent pan-Akt inhibitor. It displayed efficacy in xenograft models of prostate, breast, ovarian, colorectal, non-small cell lung, glioblastoma, and melanoma cancers.

SX-682 | CXCR1/2 inhibitor

Novel CXCR1/2 inhibitor. It displayed robust synergistic activity with immune checkpoint blockade against castration resistant prostate cancer.

Brigatinib | pan-ALK inhibitor

Potent and selective pan-ALK inhibitor. Cells with ALK mutation L1196Q2 and the double mutation I1171S + G12693 remain sensitive to brigatinib.

AS-1949490 | SHIP2 inhibitor

Potent and selective inhibitor of the intracellular phosphatase SHIP2. Displays ca. 30-fold selectivity for SHIP2 over SHIP1.

WH-4-023 | Src family inhibitor

Potent and selective Src family kinase inhibitor known to inhibit Lck, Src, SIK1, SIK2 and SIK3.

NQDI-1 | ASK1 inhibitor

Selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1). Promotes survival of induced pluripotent stem cells.

Filgotinib | JAK1 inhibitor

Potent and selective JAK1 inhibitor. Displays potent anti-inflammatory activity in various models.

CPI-613 | KGDH and PDH inhibitor

Lipoic acid analog which potently disrupts mitochondrial metabolism with selectivity for tumor cells in vitro and shows strong antitumor activity in vivo.

Dyclonine HCl | Mitochondrial function enhancer

Topical anesthetic which has been used for oral and throat analgesia. Enhances neuronal mitochondrial function, potentiating respiration and providing protection against insults associated with neurodegenerative disorders.

URMC-099 | Mixed-lineage kinase inhibitor

Potent, brain penetrant mixed-lineage kinase 3 inhibitor (MLK3). It also potently inhibits FLT3, LRRK2, and ABL1.

PFI-3 | Family VIII bromodomain inhibitor

Selective inhibitor of family VIII bromodomains PB1(5), SMARCA2, and SMARCA4. Shows complete selectivity over all non-family VIII bromodomains.

PB28 dihydrochloride | High affinity sigma 2 ligand / Anti-SARS-CoV2

Very potent high affinity (Ki = 5.3 nM1, 0.34 nM2) σ2 agonist. Selective for σ2 over σ1. PB28 inhibited cell growth in MCF7 and MCF7 ADR breast cancer cells and displayed strong synergism with doxorubicin

Liproxstatin-1 | Ferroptosis inhibitor

Inhibitor of ferroptosis. Liproxstatin-1’s mechanism of activity has been attributed to its activity as a radical-trapping antioxidant.

GSK2982772 | RIPK1 inhibitor

Highly selective inhibitor of Receptor-interacting Protein 1 kinase.

Fludarabine | DNA synthesis inhibitor

Synthetic adenosine analog that inhibits DNA biosynthesis and is a clinically useful antineoplastic agent.

FITC-Tyramide | Signal amplification reagent for immunoassays

Reagent for use in catalyzed reporter deposition (CARD) signal amplification1 protocols in a variety of immunoassays in which horseradish peroxidase catalyzes local deposition of FITC tyramide.

Xanomeline tartrate | Selective M1 muscarinic agonist

Functionally-selective M1 muscarinic receptor agonist. Displays positive cognitive and behavioral effects in schizophrenia and Alzheimer’s disease. Suppresses proinflammatory cytokine responses and improves survival in sepsis.

Emetine hydrochloride | Protein synthesis inhibitor

A useful agent for inhibiting protein synthesis in eukaryotic cells by virtue of its inhibition of the ribosome 40S subunit. Inhibits Zika and Ebola virus in vitro and in vivo, also inhibits SARS-CoV-2 replication in cells

Boceprevir | Antiviral, SARS-CoV2 Mpro inhibitor

Directly inhibits Hepatitis C virus (HCV) NS3 protease. This blocks NS3 autoactivation, and subsequent cleavage and maturation of other viral proteins necessary for replisome assembly.

Remodelin | Acetyltransferase NAT10 inhibitor

Potent and selective inhibitor of N-acetyltransferase 10 (NAT10) which us capable of acetylating microtubules and histones. Improves nuclear architecture, chromatin organization and fitness, normalizing progeric and aging cells.

Guggulsterone-(Z) | FXR antagonist

Natural steroid which lowers cholesterol and acts as an FXR antagonist. Induces differentiation of pluripotent stem cells to dopaminergic neurons.

Omeprazole | Proton pump inhibitor/ Antiviral

H+,K+-ATPase inhibitor, clinically useful antisecretory and antiulcer agent. Displays broad spectrum antiviral activity and enhances the efficacy of remdesivir.

GKT-37831 | NADPH oxidase NOX1/4 inhibitor

GKT137831 inhibits NADPH oxidase BOX1/4 and blocks erastin-stimulated ROS production.

TIC10 | Mitochondrial caseinolytic protease P activator / Anticancer agent

Novel anti-cancer compound that acts via early-stage integrated stress response activation leading to selective cancer cell death

Roxadustat | Proyl hydroxylase domain inhibitor / HIF stabilizer

Pan-prolyl hydroxylase domain (PHD) inhibitor that stabilizes hypoxia-inducible factor (HIF) leading to erythropoiesis.

Tiagabine hydrochloride | GABA transporter 1 (GAT1) inhibitor

Clinically useful anticonvulsant that inhibits both neuronal and glial GABA re-uptake

Favipiravir | Inhibitor of viral RNA-dependent RNA polymerase

Inhibitor of viral RNA-dependent RNA polymerase with activity against influenza viruses A,B and C as wells as a wide range of other viruses.

Oseltamivir Phosphate | Neuraminidase inhibitor / Antiviral

Potent viral neuraminidase inhibitor and clinically useful treatment for influenzas A and B.

Ritonavir | HIV1/2 protease inhibitor

Clinically useful HIV-1/HIV-2 protease inhibitor. Potent inhibitor of cytochrome P450 3A4.

GRL-0496 | SARS-CoV 3CLpro inhibitor

Potent inhibitor of severe acute respiratory syndrome-coronavirus chymotrypsin-like protease.

GRL-0617 | Potent SARS-CoV PLpro inhibitor

Potent noncovalent inhibitor of severe acute respiratory syndrome-coronavirus papain-like protease. Inactive against human DUB-like proteases.

Nelfinavir mesylate | HIV protease inhibitor / Anticancer activity

Clinically useful anti-HIV acting via inhibition of HIV-1 proteases. Also displays efficacy in cancer, malaria, tuberculosis and SARS.

Prochlorperazine maleate | Endocytosis inhibtior

Inhibits dynamin and clathrin-mediated endocytosis. Increases tumor cell antigen presentation.

Tazemetostat | EZH2 inhibitor

Potent and selective SAM-competitive inhibitor of the lysine methyltransferase EZH2

Ponatinib | Bcr-Abl multikinase inhibitor

Highly potent pan-Bcr-Abl and multikinase inhibitor, suppressing the activity of native Bcr-Abl as well as the mutants T315I, Q252H, Y253F, M351T and H396P. Protects against influenza A virus-induced death by suppressing cytokine storm in mouse models.

Santacruzamate A | Ultrapotent HDAC2 inhibitor

Highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium cf. Symploca.

Brequinar sodium | Dihydroorotate dehydrogenase inhibitor, antiviral

Inhibitor of dihydroorotate dehydrogenase with broad antiviral activity against flaviviruses, positive-strand RNA alphaviruses, negative-strand RNA rhabdoviruses, influenza A and B viruses and HIV.

Roxatidine | Histamine H2 antagonist, antiulcer, anti-inflammatory

Novel histamine H2 receptor antagonist that suppresses inflammatory response via inhibition of NF&kappa>B and p38 MAPK activation in macrophages.

N⁴-Hydroxycytidine | Novel antiviral

N⁴-Hydroxycytidine is the active molecule in the antiviral pro-drug clinical candidate EIDD-2801 with action against a broad range of viruses including coronaviruses

Camostat mesylate | Serine protease inhibitor, antiviral, anti-inflammatory activity

Reduces infection of Calu-3 lung cells by SARS-CoV-2 (responsible for COVID-19) via inhibition of the serine protease TMPRSS2 required for viral spike protein priming.

Scriptaid | HDAC inhibitor

Inhibits HDACs 1,3 and 8. Induces cell cycle arrest and epigenetic changes in colon cancer cells.

Dihydroresveratrol | Resveratrol metabolite

Glucuronide conjugates of dihydroresveratrol are found in human urine after oral intake of resveratrol dietary supplements.

DY131 | Estrogen-related receptor ERRβ and ERRγ agonist

Selective agonist at estrogen-related receptors ERRβ and ERRγ with minimal activity at ERRα, ERα and ERβ. Displays antiproliferative activity in prostate cancer cells.

PK150 | Sorafenib analog with unique antibacterial properties

Displays significant antibacterial activity against S. aureus NSTC8325, vancomycin-resistant enterococci and M. tuberculosus. Inactive against Gram-negative bacteria

Leelamine | Intracellular cholesterol inhibitor

Induces cholesterol accumulation in lysosomal/endosomal cell compartments via inhibition of autophagic flux

NU7441 | DNA-PK inhibitor

Potent and selective ATP-competitive inhibitor of DNA-dependent protein kinase. Increases radio/chemosensitivity of various cancer cell lines.

Crenolanib | PDGF and FLT3 inhibitor

Potent inhibitor of PDGFR and FLT3 that binds only to the active kinase configuration.

AZ3146 | Mps 1kinase inhibitor

Potent and selective inhibitor of monopolar spindle 1 that decreases hepatocellular carcinoma growth in vitro.

AZD7762 | Checkpoint Kinase 1/2 inhibitor

Potent and selective inhibitor of checkpoint kinases 1 and 2. It abrogates DNA damage-induced S and G2 checkpoints and enhances the efficacy of DNA damaging agents such as gemcitabine and irinotecan.

SNS-314 mesylate | Aurora kinase inhibitor

Potent and selective Aurora kinase inhibitor. Able to inhibit proliferation in a wide panel of human cancer cell lines.

Elafibranor | PPARalpha/delta agonist

Able to decrease plasma triglycerides levels, increase HDL cholesterol levels in human studies, and improve hepatic and peripheral insulin sensitivity.

Levetiracetam | Anticonvulsant

Clinically useful non classical anticonvulsant believed to act through binding to SV2A. No effect on voltage-dependent Na+ channels, GABAergic transmission, or affinity for either GABAergic or glutaminer rgic eceptor.

Tigecycline | Antibiotic

Clinically useful antibiotic that has also been shown to be selectively toxic to human acute myeloid leukemia cells over normal hematopoietic cells.

Volasertib | Potent and selective inhibitor of Polo-like kinase 1

Potent and selective inhibitor of Polo-like kinase 1 that has shown efficacy in multiple solid xenograft tumor models and in clinical studies of patients with acute myeloid leukemia.

Fruquintinib | Potent and selective inhibitor of VEGFR kinase

Potently and selectively inhibits VEGF/VEGFR signaling and cell proliferation in HUVECs and HLECs and prevents angiogenesis in vitro.

AZ20 | ATR kinase inhibitor

Combination therapy with AZ20 and gemcitabine resulted in synergistic inhibition of tumor cell growth and cell death initiation in pancreatic cancer cell lines.

AZD1152-HQPA | Aurora B kinase inhibitor

Highly selective inhibitor of Aurora kinase B that inhibits the growth of tumors in multiple cancer models.

Lomeguatrib | MGMT inhibitor

Potent inhibitor of O6-Methylguanine-DNA Methyltransferase (MGMT), an important DNA repair protein.

Methoprene Acid | Selective RXR agonist

Binds directly and selectively to the retinoid X receptor (RXR) acting as a transcriptional activator with no activity at RAR. Negatively regulates thrombosis and hemostasis.

ML-335 | Trek-1,2 activator

Novel, selective TREK-1,2 activator with EC50s of 14.3 and 5.2 µM

NOTUMib-1 | NOTUM inhibitor, restores Wnt signaling

Inhibits the carboxylesterase activity of NOTUM, IC50=0.085 µM, and restores Wnt signaling.

MitoBloCK-12 | Mitochondrial import inhibitor

Blocks translocation of a mutant form of alanine: glyoxylate aminotransferase (AGT) to the mitochondria and restores AGT trafficking to peroxisomes.

N-Eicosanoyl serotonin | Neuroprotective

Inhibits the PP2A methylesterase maintaining PP2A in a highly active state leading to hyperphosphorylat αed -synuclein.

DO264 | ABHD12 inhibitor

Potent, reversible competitive inhibitor of ABHD12 (α/β-hydrolase domain-containing 12) which shows negligible interaction with other serine hydrolases.

Rucaparib phosphate | PARP1 inhibitor

Potent PARP1 inhibitor. Cytotoxic to human cancer cells or xenograft tumors with mutated or epigenetically silenced BRCA1/2.

Pomalidomide | Cereblon ubiquitination inhibitor

Inhibits the E3 ubiquitin ligase cereblon (CRBN). Displays antiangiogenic and immunomodulatory activity in vivo potently inhibiting the production of TNF alpha and IL-2.

Imiquimod | TLR7 agonist

Toll-like receptor 7/8 agonist with anti-viral and anti-tumor properties. Enhances innate immune system leading to Th1-mediated antitumor immune response.

Norfluoxetine HCl | Fluoxetine Metabolite

Induces long QT syndrome via slow delayed rectifier potassium current block. Time dependent inhibitor of CYP2C19 and CYP3A4.

Acalabrutinib | Highly selective BTK inhibitor

Hghly selective, potent (IC50 = 3nM), and irreversible inhibitor of Bruton’s tyrosine kinase (BTK). Significantly inhibits BCR signaling, inhibits tumor proliferation, and reduces tumor burden.

Ibrutinib | BTK inhibitor

Very potent (IC50 = 0.5nM) irreversible inhibitor of Bruton tyrosine kinase (BTK) that blocks activation of the B-cell antigen receptor (BCR).