5-Thio-D-glucose | Glucose transport inhibitor

5-Thio-D-glucose (20408-97-3) is a potent competitive inhibitor of the cellular transport of glucose and glucose-mediated insulin release.1 May be used to induce a state of glucose deprivation in laboratory animals.2 Stimulates feeding in rat models.3  Induces Alzheimer-like changes in frontal cortex and hippocampus in rats.4  Elevates renal TGF-b1 at a dose that does not prevent streptozotocin diabetes in rats.5

References:

  1. Wang et al. (1995) Glucose transporter 2 expression: prevention of streptozotocin-induced reduction in beta-cells with 5-thio-D-glucose; Clin. Endocrinol. Diabetes, 103 83 Suppl.2
  2. Shah et al. (2019), Recurrent glucose deprivation leads to the preferential use of lactate by neurons in the ventromedial hypothalamus; J. Physiol. Endocrinol. Metab., 316 E948
  3. Li et al. (2014), Stimulation of feeding by three different glucose-sensing mechanisms requires hindbrain catecholamine neurons; J. Physiol. Regul. Integr. Comp. Physiol., 306 R257
  4. Salkovic-Petrisic et al. (2006), Alzheimer-like changes in protein kinase B and glycogen synthase kinase-3 in rat frontal cortex and hippocampus after damage to the insulin signaling pathway; J. Neurochem., 96 1005
  5. Lane et al. (2000), 5-thio-D-glucose elevates renal transforming growth factor beta-1 at a dose that does not prevent streptozotocin diabetes in rats; Endocrinology, 141 3337
Weight 0.1 mg
Dimensions 0.1 × 0.1 × 0.1 cm
Size:

20 mg, 100 mg

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CAS:
20408-97-3
Catalog Number:
10-1398
Activity:
Glucose transport inhibitor
Chemical Names:

5-Thio-5-deoxy-D-glucose; 5TG

Molecular Weight:
196.22
Molecular Formula:
C6H12O5S
Solubility:
Soluble in Water (up to 15 mg/ml)
Physical Properties:
White solid
Purity:
97% HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months.
Shipping Code:
RT

5-Thio-D-glucose | Glucose transport inhibitor

$80.00$320.00

CAS:
20408-97-3
Catalog Number:
10-1398
Activity:
Glucose transport inhibitor
Chemical Names:

5-Thio-5-deoxy-D-glucose; 5TG

Molecular Weight:
196.22
Molecular Formula:
C6H12O5S
Solubility:
Soluble in Water (up to 15 mg/ml)
Physical Properties:
White solid
Purity:
97% HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months.
Shipping Code:
RT
  • 20 mg
  • 100 mg
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