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(5Z)-7-Oxozeaenol | TAK1 inhibitor

CAS:
253863-19-3
Catalog Number:
10-3023
Activity:
TAK1 inhibitor
Chemical Names:
(3S,5Z,8S,9S,11E)-3,4,9,10-Tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
Alternate Name:
LL-Z-1640-2
Molecular Weight:
362.38
Molecular Formula:
C19H22O7
Solubility:
Soluble in DMSO (9 mg/ml); ethanol (3 mg/ml)
Physical Properties:
White to off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

(5Z)-7-Oxozeaenol (253863-19-3) is a potent and selective inhibitor of TAK1 (mitogen activated protein kinase kinase kinase) IC50 = 8 nM.1 Selective over MEKK1 and MEKK4. Blocks IL-1-induced activation of TAK1 in cell culture.1 Blocks the production of pro-inflammatory cytokines and displays anti-inflammatory activity in various models.2-4

References/Citations:

  1. Ninomiya-Tsuji et al. (2003), A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase; J. Biol. Chem., 278 18485
  2. Windheim et al. (2007), Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide; Biochem. J., 404 179
  3. Xu et al. (2016), Blockade of TGF-ß-activated kinase 1 prevents advanced glycation end products-induced inflammatory response in macrophages; Cytokine, 78 62
  4. Ivshina et al. (2015), CPEB regulation of TAK1 synthesis mediates cytokine production and the inflammatory immune response; Mol. Cell. Biol., 35 610
(5Z)-7-Oxozeaenol | TAK1 inhibitor is also available in the Cellular Metabolism Library.
CAS:
253863-19-3
Catalog Number:
10-3023
Activity:
TAK1 inhibitor
Chemical Names:
(3S,5Z,8S,9S,11E)-3,4,9,10-Tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
Alternate Name:
LL-Z-1640-2
Molecular Weight:
362.38
Molecular Formula:
C19H22O7
Solubility:
Soluble in DMSO (9 mg/ml); ethanol (3 mg/ml)
Physical Properties:
White to off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

N/A
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