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Reagents
Biochemical Targets
Autophagy
Bioactive Lipids
Cellular Metabolism
Cellular trafficking
Cytoskeleton
DNA Damage/Repair
Epigenetics
Gene regulation
GPCRs
Ions and other channels
Kinases
Mitochondria
Nuclear receptors
Transcription factors
Ubiquitin/Proteasome
View All
Physiological Processes
Angiogenesis
Cancer
Cardiovascular
Cell Cycle
Cellular Senescence
Cellular Stress
Circadian clock
Diabetes
Immunology
Inflammation
Neurodegeneration
Obesity and metabolic diseases
Pain
Programmed Cell Death
Stem cells
View All
Chemical Libraries
Custom Synthesis
Resource Center
About
Resources
News & Events
Distributors
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Contact Us
Customer Support
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New Products
We will continue to add new products to our already extensive portfolio – check back often for the latest breakthroughs. If you can’t find what you need,
contact us
for information on custom synthesis.
iPHF8 | Inhibitor of lysine demethylase PHF8
iPHF8 is a specific inhibitor (IC50 = 2.01 µM; EC50 = 2 µM in HeLa cells) of the human non-heme 2-oxoglutarate JmjC domain oxygenase/lysine demethy...
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Lomitapide | Microsomal triglyceride transfer protein inhibitor
Lomitapide (182431-12-5) is a potent (IC50 = 8 nM) inhibitor of microsomal triglyceride transfer protein (MTP or MTTP) and is clinically useful in ...
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HC-258 | Covalent TEAD inhibitor
HC-258 is a covalent inhibitor of TEAD (transcriptional enhanced associate domain), an important component of the Hippo pathway. It was able to re...
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RECTAS | pre-mRNA splicing modulator
RECTAS (101862-47-9), a pre-mRNA splice modulator (Rectifier of Aberrant Splicing), was discovered in a small molecule screen for compounds that re...
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JNK-IN-8 | Covalent JNK inhibitor
JNK-IN-8 (1410880-22-6) is a potent and selective irreversible JNK inhibitor (IC50s=4.67, 18.7 and 0.98 nM for JNK1, 2 and 3 respectively).1 JNK ...
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Gue1654 | OXE-R biased antagonist
Gue1654 (397290-30-1) is a biased antagonist for the oxoeicosanoid receptor 1 (OXE-R, GPR170)1, the receptor for 5-Oxo-ETE, a proinflammatory eicos...
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UNC0224 | G9a histone methyl transferase inhibitor
UNC0224 (1197196-48-7) is a potent inhibitor of histone methyltransferases G9a / EHMT2 (IC50 = 15 nM) and GLP / EHMT1 (IC50 ~ 39 nM) but not SET7/9...
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7-Dehydrocholesterol | Ferroptosis inhibitor
7-Dehydrocholesterol (434-16-2) is an endogenous cholesterol precursor and is photochemically converted to vitamin D3 in the skin.1 It has recentl...
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Cycloastragenol | Telomerase activator/Senolytic agent
Cycloastragenol (84605-18-5) is a novel naturally occurring terpenoid found in Astragalus which was shown to be a telomerase activator. In CD8+ T ...
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Migalastat HCl | Galactosidase inhibitor/Pharmacological chaperone
Migalastat (75172-81-5) is a potent, selective, and orally available inhibitor of α-galactosidase A (IC50= 40 nM).1 It binds to mutant misfolded α-...
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ML401 | EBI2 (GPR183) antagonist
ML401 (1597489-14-9) is a potent antagonist of GPR183 (IC50 = 1.03 nM), also known as EBI2 or Epstein-Barr virus-induced gene 2. ML401 inhibited ...
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Cafestol | Neuroprotective
Cafestol (469-83-0) is a bioactive diterpene found in coffee.1 It displays a number of interesting protective effects including stimulation of glut...
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icFSP1 | Ferroptosis suppressor protein (FSP1) inhibitor
Ferroptosis suppressor protein-1 (FSP1) along with ubiquinone and NAD(P)H/H+ has been identified as a second ferroptosis suppressing system which p...
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Indisulam | RBM39 Molecular glue
Indisulam (165668-41-7) was originally described as a potent antitumor agent that targeted the G1 phase of cell cycle via suppression of activation...
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TRIM-473 | RING ligase TRIM58 ligand
TRIM-473 is a ligand (EC50 = 5.3 µM) for the PRY-SPRY domain of the RING ligase TRIM58. An interesting new tool for the development of heterobifun...
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GSK2636771 | Potent and selective inhibitor of PI3Kß
GSK2636771 (1372540-25-4) is a potent, selective (>1000-fold over α, 10-fold over δ, and >2000-fold over γ), and orally bioavailable inhibito...
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LDC1267 | Inhibitor of TAM kinases
LDC1267 (1361030-48-9) is a potent and selective inhibitor of the TAM kinases Tyro3, Axl, and Mer (IC50s respectively: 8 nM, <5 nM, 29 nM).1 It ...
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XMU-MP-1 | Potent and selective MST1/2 kinase inhibitor
XMU-MP-1 (2061980-01-4) is a potent, reversible, and selective inhibitor of the HIPPO pathway kinases MST1 and MST2 (IC50s = 71 nM and 38 nM respec...
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Selpercatinib | Potent and selective RET kinase inhibitor
Selpercatinib (2152628-33-4) is a potent (IC50 = 0.45 nM)1 and selective inhibitor of RET kinase.2 Clinically relevant for the treatment of RET-alt...
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Decoyinine | Inhibitor of GMP synthase
Decoyinine (2004-04-8) is a non-competitive and reversible inhibitor of GMP synthase (GMPS, IC50=17.3 µM).1 GMPS was shown to be a positive regula...
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