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ABT-737 | Senolytic Bcl2 inhibitor

CAS:
852808-04-9
Catalog Number:
10-3661
Activity:
Senolytic Bcl inhibitor
Chemical Names:
4-[4-[(4′-Chloro[1,1′-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-benzamide
Molecular Weight:
813.43
Molecular Formula:
C42H45ClN6O5S2
Solubility:
Soluble in DMSO (5 mg/ml)
Physical Properties:
Yellow solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

ABT-737 (852808-04-9) is an inhibitor of anti-apoptotic proteins from the Bcl family: Bcl-2, Bcl-X(L), and Bcl-w (Ki < 1 nM) that causes regression of solid tumors in mice.1 Senolytic agent which disrupts aberrant p21 expression, inducing apoptosis in senescent cells, and enhancing liver regeneration in mice.2,3 Acts synergistically to reduce cell viability when combined with CDK inhibitor purvalanol A in preclinical models of acute myeloid leukemia (AML).4

References/Citations:

  1. Oltersdorf et al. (2005), An inhibitor of Bcl-2 family proteins induces regression of solid tumors; Nature, 435 677
  2. Yosef et al. (2016), Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL; Nat. Commun., 7 11190
  3. Ritschka et al. (2020), The senotherapeutic drug ABT-737 disrupts aberrant p21 expression to restore liver regeneration in adult mice; Genes Dev., 34 489
  4. Lappin et al. (2020), A compound combination screening approach with the potential to identify new treatment options for paediatric acute myeloid leukaemia; Sci. Rep., 10 18514
ABT-737 | Senolytic Bcl2 inhibitor is also available in the Cellular Metabolism Library.
CAS:
852808-04-9
Catalog Number:
10-3661
Activity:
Senolytic Bcl inhibitor
Chemical Names:
4-[4-[(4′-Chloro[1,1′-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-benzamide
Molecular Weight:
813.43
Molecular Formula:
C42H45ClN6O5S2
Solubility:
Soluble in DMSO (5 mg/ml)
Physical Properties:
Yellow solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

N/A
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