Adavosertib | Wee1 kinase inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $45.00 | ||
| 25 mg | $155.00 |
Adavosertib (955365-80-7) inhibits Wee1 tyrosine kinase (IC50 = 5.2 nM) thus preventing phosphorylation of CDC2 and abrogating the G2 DNA damage checkpoint, sensitizing a variety of tumor cells to DNA damaging agents.1 Adavosertib also blocks Wee1 phosphorylation of E3 ubiquitin ligase SKP2 in human cells, ultimately preventing degradation of CDKs and further allowing cell cycle progression.2 Stimulates anti-tumor immunity and enhances sensitivity to immune checkpoint blockade by activating ERV and the dsRNA pathway.3 Potentiates sensitivity of tumors to PARP inhibitors.4
References/Citations:
- Hirai et al. (2009) Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents; Cancer Ther. 8 2992
- Pan et al. (2021) A novel WEE1 pathway for replication stress responses; Plants 7 209
- Guo et al. (2022) WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway; Exp. Med. 219 e20210789
- Seo et al. (2021) Inhibition of WEE1 Potentiates Sensitivity to PARP Inhibitor in Biliary Tract Cancer; Cancer Res. Treat. Epub ahead of print
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Adavosertib (955365-80-7) inhibits Wee1 tyrosine kinase (IC50 = 5.2 nM) thus preventing phosphorylation of CDC2 and abrogating the G2 DNA damage checkpoint, sensitizing a variety of tumor cells to DNA damaging agents.1 Adavosertib also blocks Wee1 phosphorylation of E3 ubiquitin ligase SKP2 in human cells, ultimately preventing degradation of CDKs and further allowing cell cycle progression.2 Stimulates anti-tumor immunity and enhances sensitivity to immune checkpoint blockade by activating ERV and the dsRNA pathway.3 Potentiates sensitivity of tumors to PARP inhibitors.4
References/Citations:
- Hirai et al. (2009) Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents; Cancer Ther. 8 2992
- Pan et al. (2021) A novel WEE1 pathway for replication stress responses; Plants 7 209
- Guo et al. (2022) WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway; Exp. Med. 219 e20210789
- Seo et al. (2021) Inhibition of WEE1 Potentiates Sensitivity to PARP Inhibitor in Biliary Tract Cancer; Cancer Res. Treat. Epub ahead of print
Related products
-
Tigecycline | Antibiotic
From $50.00CAS:220620-09-7Catalog Number:10-3900Activity:AntibioticChemical Name:(4S,4aS,5aR,12aR)-9-[[2-(tert-Butylamino)acetyl]amino]-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamideAlternate Names:9-t-Butylglycylamidominocycline; GAR-936Molecular Weight:585.66Molecular Formula:C29H39N5O8Solubility:Soluble in DMSO (up to at least 25 mg/ml).Physical Properties:Orange solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT -
AZ3146 | Mps1 kinase inhibitor
From $60.00CAS:1124329-14-1Catalog Number:10-4778Activity:Mps1 kinase inhibitorChemical Name:9-Cyclopentyl-2-[2-methoxy-4-(1-methylpiperidine-4-yl)oxyanilino]-7-methylpurin-8-oneMolecular Weight:452.56Molecular Formula:C24H32N6O3S2Solubility:Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to at least 25 mg/ml)Physical Properties:Off-white solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.Shipping Code:RT -
NOTUMib-1 | NOTUM inhibitor, restores Wnt signaling
From $55.00Catalog Number:10-3756Activity:NOTUM inhibitor, restores Wnt signalingChemical Name:N-(Isoquinolin-6-yl)-2-(o-tolyloxy)acetamideMolecular Weight:292.33Molecular Formula:C18H16N2O2Solubility:Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 5 mg/ml with warming).Physical Properties:Beige solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20° (des.)Stability:Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
Website Created by Advanta Advertising LLC.