AR7 | Activates chaperone mediated autophagy
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $70.00 | ||
| 25 mg | $280.00 |
AR7 (80306-38-3) is an atypical retinoid which acts as an RARα antagonist and activates chaperone-mediated autophagy (CMA) via an RAR-dependent pathway.1 Downstream signaling results in an increase of LAMP-2A expression.1 Cells pretreated with AR7 had markedly improved viability in a paraquat-induced oxidative stress model.1 AR7 stimulated CMA and attenuated accumulation of SNCA oligomers in prolonged cultures of mutant cortical neurons2 indicating that CMA activation may be a viable disease modifying strategy in Parkinson’s disease3. A targetome analysis of AR7-induced CMA in cancer cells has been performed.4
References/Citations:
- Anguiano et al. (2013), Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives; Nat. Chem. Biol. 9 374
- Ho et al. (2020), Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA); Autophagy 16 347
- Bonam et al. (2021), Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson’s Disease; Cells 10 3547
- Hao et al. (2019), Targetome analysis of chaperone-mediated autophagy in cancer cells; Autophagy 15 1558
NMR (Conforms)
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Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
AR7 (80306-38-3) is an atypical retinoid which acts as an RARα antagonist and activates chaperone-mediated autophagy (CMA) via an RAR-dependent pathway.1 Downstream signaling results in an increase of LAMP-2A expression.1 Cells pretreated with AR7 had markedly improved viability in a paraquat-induced oxidative stress model.1 AR7 stimulated CMA and attenuated accumulation of SNCA oligomers in prolonged cultures of mutant cortical neurons2 indicating that CMA activation may be a viable disease modifying strategy in Parkinson’s disease3. A targetome analysis of AR7-induced CMA in cancer cells has been performed.4
References/Citations:
- Anguiano et al. (2013), Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives; Nat. Chem. Biol. 9 374
- Ho et al. (2020), Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA); Autophagy 16 347
- Bonam et al. (2021), Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson’s Disease; Cells 10 3547
- Hao et al. (2019), Targetome analysis of chaperone-mediated autophagy in cancer cells; Autophagy 15 1558
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
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