Autogramin-2 | Autophagy blocker / GRAMD1A inhibitor

Autogramin-2 (2375541-45-8) is an inhibitor of autophagy (autophagy induced by amino acid starvation IC50 = 270 nM; Rapamycin IC50 = 140 nM) acting via selective targeting of the cholesterol transfer protein GRAM domain-containing protein 1A (GRAMD1A).  Autogramin-2 inhibition of GRAMD1A inhibits biogenesis of the autophagosome.

References/Citations for Autogramin-2

  1. Laraia et al. (2019), The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis; Chem. Biol., 15 710
Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
Size :

5 mg, 25 mg

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CAS:
2375541-45-8
Catalog Number:
10-4439
Activity:
Autophagy blocker / GRAMD1A inhibitor
Chemical Name:

t-Butyl 2-[(4-propan-2-yloxybenzoyl)amino]-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-5-carboxylate

Molecular Weight:
417.53
Molecular Formula:
C21H27N3O4S
Solubility:
Soluble in DMSO (up t0 25 mg/ml) or in Ethanol (up to 25 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Autogramin-2 | Autophagy blocker / GRAMD1A inhibitor

$70.00$275.00

CAS:
2375541-45-8
Catalog Number:
10-4439
Activity:
Autophagy blocker / GRAMD1A inhibitor
Chemical Name:

t-Butyl 2-[(4-propan-2-yloxybenzoyl)amino]-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-5-carboxylate

Molecular Weight:
417.53
Molecular Formula:
C21H27N3O4S
Solubility:
Soluble in DMSO (up t0 25 mg/ml) or in Ethanol (up to 25 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
  • 5 mg
  • 25 mg
Clear
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