Autogramin-2 (2375541-45-8) is an inhibitor of autophagy (autophagy induced by amino acid starvation IC50 = 270 nM; Rapamycin IC50 = 140 nM) acting via selective targeting of the cholesterol transfer protein GRAM domain-containing protein 1A (GRAMD1A). Autogramin-2 inhibition of GRAMD1A inhibits biogenesis of the autophagosome.
References/Citations for Autogramin-2
- Laraia et al. (2019), The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis; Chem. Biol., 15 710