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AZD5904 | Myeloperoxidase inhibitor

CAS:
618913-30-7
Catalog Number:
10-4058
Activity:
Myeloperoxidase inhibitor
Chemical Names:
3-[[(2R)-Oxolan-2-yl]methyl]-2-sulfanylidene-7H-purin-6-one; 3-[[(2R)-Tetrahydrofuran-2-yl]methyl]-2-thioxo-7H-purin-6-one
Alternate Name:
TX4
Molecular Weight:
252.29
Molecular Formula:
C10H12N4O2S
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Yellow solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

AZD5904 (618913-30-7) is a mechanism-based inactivator of myeloperoxidase (IC50 = 200 nM), reacting with hydrogen peroxide in neutrophils to inactivate the enzyme.1 This prevents production of hypochlorous acid and concomitant oxidative stress.  Importantly, neutrophil bactericidal activity was slowed but not stopped. AZD5904 did not inactivate thyroid peroxidase or lactoperoxidase.  AZD5904 prevented the onset and reversed established high-fat diet induced microvascular insulin resistance.2 It also alleviated the relaxation defect in hypertrophic induced pluripotent cardiomyocytes via restoration of MYBPC3 phosphorylation, suggesting potential therapeutic value in treating hypertrophic cardiomyopathy.3

References/Citations:

  1. Tiden et al. (2011), 2-Thioxanthines Are Mechanism-based Inactivators of Myeloperoxidase That Block Oxidative Stress during Inflammation; J. Biol. Chem. 286 37578
  2. Chai et al. (2019), Inhibiting myeloperoxidase prevents onset and reverses established high-fat diet-induced microvascular insulin resistance; Am. J. Physiol. Endocrinol. Metab., 317 E1063
  3. Ramachandra et al. (2022), Inhibiting cardiac myeloperoxidase alleviates the relaxation defect in hypertrophic cardiomyocytes; Cardiovasc. Res. 118 517
AZD5904 | Myeloperoxidase inhibitor is also available in the Cellular Metabolism Library.
CAS:
618913-30-7
Catalog Number:
10-4058
Activity:
Myeloperoxidase inhibitor
Chemical Names:
3-[[(2R)-Oxolan-2-yl]methyl]-2-sulfanylidene-7H-purin-6-one; 3-[[(2R)-Tetrahydrofuran-2-yl]methyl]-2-thioxo-7H-purin-6-one
Alternate Name:
TX4
Molecular Weight:
252.29
Molecular Formula:
C10H12N4O2S
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Yellow solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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