Carboxy-PTIO Potassium Salt | Nitric oxide scavenger

A nitric oxide (NO) scavenger.  Carboxy-PTIO (148819-94-7) reacts with NO with 1:1 stoichiometry1 producing NO2/NO3.   In LPS-induced endotoxin shock, carboxy-PTIO reversed hypotension and renal dysfunction and increased survival in a rat model.2 A very useful tool for probing the involvement of NO in physiological processes.3,4

References:

  1. Akaike et al. (1993), Antagonistic action of imidazolineoxyl N-oxides afainst endothelium-derived relaxing factor/.NO through a radical reaction, Biochemistry, 32 827
  2. Yoshida et al. (1994), Therapeutic effects of imidazolineoxyl N-oxide against endotoxin shock through its direct nitric oxide-scavenging activity; Biophys. Res. Commun., 202 923
  3. Hada et al. (2019), Nitric Oxide Is Involved in Heavy Ion-Induced Non-Targeted Effects in Human Fibroblasts; J. Mol. Sci., 20 4327
  4. Jin et al. (2020), A novel quinolinylmethyl substituted ethylenediamine compound exerts anti-cancer effects via stimulating the accumulation of reactive oxygen species and NO in hepatocellular carcinoma cells; J. Pharmacol., 885 173497
Weight 0.1 mg
Dimensions 0.1 × 0.1 × 0.1 cm
Size:

10 mg, 50 mg

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CAS:
148819-94-7
Catalog Number:
10-3037
Activity:
Nitric oxide scavenger
Chemical Names:

2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, potassium salt

Molecular Weight:
315.39
Molecular Formula:
C14H16KN2O4
Solubility:
Soluble in Water (up to 100 mg/ml) or in DMSO (up to 50 mg/ml)
Physical Properties:
Blue solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Carboxy-PTIO Potassium Salt | Nitric oxide scavenger

$48.00$160.00

CAS:
148819-94-7
Catalog Number:
10-3037
Activity:
Nitric oxide scavenger
Chemical Names:

2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, potassium salt

Molecular Weight:
315.39
Molecular Formula:
C14H16KN2O4
Solubility:
Soluble in Water (up to 100 mg/ml) or in DMSO (up to 50 mg/ml)
Physical Properties:
Blue solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
Shipping Code:
RT
  • 10 mg
  • 50 mg
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