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Chromomycin A3 | DNA Stain

CAS:
7059-24-7
Catalog Number:
10-2064
Activity:
DNA stain
Chemical Names:
Aburamycin B; CMA3; NSC-58514
Molecular Weight:
1183.25
Molecular Formula:
C57H82O26
Solubility:
Soluble in DMSO (20 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Chromomycin A3 (7059-24-7) is a DNA-binding agent specific for GC-rich sequences1 which may be used as a DNA stain2. Inhibits neuronal apoptosis induced by oxidative stress and DNA damage.3 Inhibits NFkB signaling.4 Used in a reliable method for evaluating sperm DNA integrity.5

References:

  1. Van Dyke et al. (1983), Chromomycin, Mithramycin and olivomycin binding sites on heterogeneous deoxyribonucleic acid. Footprinting with methidiumpropyl-EDTA)iron(II);  Biochemistry, 22 2373
  2. Crissman and Tobey (1990), Specific staining of DNA with the fluorescent antibiotic, mithramycin, chromomycin, and olivomycin; Methods Cell Biol., 33 97
  3. Chatterjee et al. (2001), Sequence-selective DNA binding drugs mithramycin A and chromomycin A3 are potent inhibitors of neuronal apoptosis induced by oxidative stress and DNA damage in cortical neurons; Neurol., 49 345
  4. Miller et al. (2010), Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action; Pharmacol., 79 1272
  5. Dutta et al. (2020), Comparative analysis of tests used to assess sperm chromatin integrity and DNA fragmentation; Andrologia, 53 e13718
Chromomycin A3 | DNA Stain is also available in the Cellular Metabolism Library.
CAS:
7059-24-7
Catalog Number:
10-2064
Activity:
DNA stain
Chemical Names:
Aburamycin B; CMA3; NSC-58514
Molecular Weight:
1183.25
Molecular Formula:
C57H82O26
Solubility:
Soluble in DMSO (20 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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