DJ001 | PTPsigma inhibitor / Promotes stem cell regeneration

DJ001 (2161306-12-8) is a potent and specific inhibitor of receptor type protein tyrosine phosphatase-sigma (PTPσ) IC50=1.54 µM and >10 µM for 20 other phosphatases.1  Promotes hematopoietic stem cell regeneration in vivo. In mice treated with 5-fluorouracil or irradiated, DJ001 promoted HSC regeneration accelerated hematologic recovery and improved survival. The mode of inhibition of PTPs is via non-competitive allosteric binding. Suppression of radiation-induced HSC apoptosis occurs via activation of Rho GTPase, Rac1 and induction of BCL-XL. Treatment of irradiated human HSCs with DJ001 promotes the regeneration of human HSCs capable of multilineage in vivo repopulation.1

References/Citations for DJ001

  1. Zhang et al. (2019), PTPσ inhibitors promote hematopoietic stem cell regeneration;  Nat. Commun., 10 3667
Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
size :

5 mg, 25 mg

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CAS:
2161305-12-8
Catalog Number:
10-3800
Activity:
PTPσ inhibitor | promotes stem cell regeneration
Chemical Name:

(Z)-3-((3-Nitrophenyl)amino)-1-phenylprop-2-en-1-one

Molecular Weight:
268.27
Molecular Formula:
C15H12N2O3
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml with warming)
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

DJ001 | PTPsigma inhibitor / Promotes stem cell regeneration

$70.00$300.00

CAS:
2161305-12-8
Catalog Number:
10-3800
Activity:
PTPσ inhibitor | promotes stem cell regeneration
Chemical Name:

(Z)-3-((3-Nitrophenyl)amino)-1-phenylprop-2-en-1-one

Molecular Weight:
268.27
Molecular Formula:
C15H12N2O3
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml with warming)
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
  • 5 mg
  • 25 mg
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