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Domoic acid | Marine natural product neurotoxin

CAS:
 14277-97-5
Catalog Number:
 10-2472

Domoic acid (DA; 14277-97-5)), a kainic acid-type neurotoxin produced by certain species of the marine pennate diatom Pseudo-nitzschia, is responsible for amnesic shellfish poisoning.1 Suspension feeders such as bivalve mollusks can accumulate and retain high amounts of DA in their tissues, threatening human health.2,3 DA is a potent agonist at kainate and AMPA receptors4 and induces convulsive behavior and seizures in rodents5. It induces structural and molecular changes in the developing zebra fish nervous system.6

References/Citations:

  1. Nie et al. (2022), Biosynthesis and detection of domoic acid from diatom Pseudo-nitzschia: A review; Curr. Pharm. Biotechnol., June 24 online ahead of print
  2. Garcia-Corona et al. (2022), First subcellular localization of the amnesic shellfish toxin, domoic acid, in bivalve tissues: Deciphering the physiological mechanisms involved in its long-retention in the king scallop Pecten Maximus; Harmful Algae, 116 102251
  3. Guillotin and Delcourt (2021), Marine Neurotoxins’ Effects on Environmental and Human Health: an OMICS Overview; Drugs, 20 18
  4. Hampson et al. (1992), Interaction of domoic acid and several derivatives with kainic acid and AMPA binding sites in rat brain; Eur. J. Pharmacol., 218 1
  5. Chiamulera et al. (1992), Domoic acid toxicity in rats and mice after intracerebroventricular administration: comparison with excitatory amino acid agonists; Pharmacol. Toxicol., 70 115
  6. Panlilio et al. (2020), Developmental Neurotoxicity of the Harmful Algal Bloom Toxin Domoic Acid: Cellular and Molecular Mechanisms Underlying Altered Behavior in the Zebrafish Model; Environ. Health Perspect., 128 117002
Domoic acid | Marine natural product neurotoxin is also available in the Cellular Metabolism Library.
CAS:
14277-97-5
Catalog Number:
10-2472
Activity:
Marine natural product neurotoxin
Chemical Names:
(2S,3S,4S)-2-Carboxy-4-[(1Z,3E,5R)-5-carboxy-1-methyl-1,3-hexadien-1-yl]-3-pyrrolidineacetic acid
Molecular Weight:
311.33
Molecular Formula:

C15H21NO6

Solubility:
Solution in water with 5% acetonitrile at 50 µg/0.5 mL
Physical Properties:
Solution in water
Purity:

>97% HPLC
NMR (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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