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EGA | Endosomal trafficking inhibitor

CAS:
415687-81-9
Catalog Number:
10-3689
Activity:
Endosomal trafficking inhibitor
Chemical Names:
2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide
Molecular Weight:
346.23
Molecular Formula:
C16H16BrN3O
Solubility:
Soluble in DMSO (50 mg/ml); Ethanol (10 mg/ml with warming)
Physical Properties:
White solid
Purity:
>95% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

EGA (415687-81-9) is a novel selective inhibitor of endosomal trafficking which blocks cellular entry of lethal toxin and other acid-dependent bacterial toxins and viruses into mammalian cells.1 Inhibits Anthrax lethal toxin-induced RAW264.7 cell death, IC50=1.7 mM.1 Delays lysosomal targeting and degradation of the EGF receptor indicating that it targets host membrane trafficking.1 Does not block endosomal recycling of transferrin, retrograde trafficking of ricin, phagolysosomal trafficking or phagosome permeabilization by Franciscella tularensis, nor does it neutralize acidic organelles.1 Protects mammalian cells from Clostridium difficile CDT, Clostridium perfringens Iota toxin and Clostridium botulinum C2 toxin.2 A useful tool for exploring subcellular trafficking of various bacterial toxins.3

References/Citations:

  1. Gillespie et al. (2013), Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses; Proc. Natl. Acad. Sci. USA, 110 E4904
  2. Schnell et al. (2016), EGA Protects Mammalian Cells from Clostridium difficile CDT, Clostridium perfringens Iota Toxin and Clostridium botulinum C2 Toxin; Toxins (Basel), 8 101
  3. Dixon et al. (2015), Distinct Roles for CdtA and CdtC during Intoxication by Cytolethal Distending Toxins; PLoS One, 10 e0143977
EGA | Endosomal trafficking inhibitor is also available in the Cellular Metabolism Library.
CAS:
415687-81-9
Catalog Number:
10-3689
Activity:
Endosomal trafficking inhibitor
Chemical Names:
2-[(4-Bromophenyl)methylene]-N-(2,6-dimethylphenyl)-hydrazinecarboxamide
Molecular Weight:
346.23
Molecular Formula:
C16H16BrN3O
Solubility:
Soluble in DMSO (50 mg/ml); Ethanol (10 mg/ml with warming)
Physical Properties:
White solid
Purity:
>95% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee