EHNA HCl | PDE2 inhibitor

EHNA (51350-19-7) inhibits phosphodiesterase 2 (PDE2) (IC50 = 0.8 – 5.5 µM in a variety of tissues and species) over PDE1, PDE3, or PDE4 (IC50 values > 100 µM).1,2 It also inhibits adenosine deaminase (ADA), IC50 = 1.2 and 1.5 µM in human RBCs and astrocytoma cells, respectively3, which may be responsible for its ability to induce apoptosis in malignant pleural mesothelioma cell lines4. Because it blocks breakdown of adenosine to inosine and hypoxanthine, EHNA prevents formation of free radical substrates, protecting against cardiac reperfusion-mediated injury.5 It inhibits differentiation and maintains expression of pluripotency markers in hESCs, but not through inhibition of PDEs or ADA.6

References:

  1. Podzuweit et al. (1995), Isoenzyme selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythron-9-(2-hydroxy-3-nonyl) adenine; Cell Signal., 7 733
  2. Méry et al. (1995), Erythro-9-(2-hydroxy-3-nonyl)adenine inhibits cyclic GMP-stimulated phosphodiesterase in isolated cardiac myocytes; Pharmacol., 48 121
  3. Barankiewicz et al. (1997), Regulation of adenosine concentration and cytoprotective effects of novel reversible adenosine deaminase inhibitors; Pharmacol. Exp. Ther., 283 1230
  4. Nakajima et al. (2015), Adenosine deaminase inhibitor EHNA exhibits a potent anticancer effect against malignant pleural mesothelioma; Cell Physiol. Biochem., 35 51
  5. Abd-Elfattah and Wechsler (1994), Separation between ischemic and reperfusion injury by site specific entrapment of endogenous adenosine and inosine using NBMPR and EHNA; Card. Surg., 9 387
  6. Burton et al. (2010), Erythro-9-(2-hydroxy-3-nonyl)adenine(EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells; J., 432 575
Weight 0.1 mg
Dimensions 0.1 × 0.1 × 0.1 cm
Size:

10 mg, 50 mg

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CAS:
51350-19-7
Catalog Number:
10-2438
Activity:
PDE2 inhibitor
Chemical Names:
Erythro-9-(2-hydroxy-3-nonyl)adenine, hydrochloride; NSC 263164
Molecular Weight:
318.87
Molecular Formula:
C14H28N5O ∙ HCl
Solubility:
Soluble in Water (up to 25 mg/ml)
Physical Properties:
Pale yellow or off-white solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

EHNA HCl | PDE2 inhibitor

$60.00$240.00

CAS:
51350-19-7
Catalog Number:
10-2438
Activity:
PDE2 inhibitor
Chemical Names:
Erythro-9-(2-hydroxy-3-nonyl)adenine, hydrochloride; NSC 263164
Molecular Weight:
318.87
Molecular Formula:
C14H28N5O ∙ HCl
Solubility:
Soluble in Water (up to 25 mg/ml)
Physical Properties:
Pale yellow or off-white solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT
  • 10 mg
  • 50 mg
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