Enzalutamide | Non-steroidal antiandrogen

Enzalutamide (915087-33-1) is a clinically useful non-steroidal antiandrogen (IC50 = 36 nM) for the treatment of castration-resistant prostate cancer.1,2 It impairs binding of the androgen receptor to DNA, the recruitment of co-activators, and reduces the efficiency of nuclear translocation.

References:

  1. Tran et al. (2009), Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer; Science 324 787
  2. Jung et al. (2010), Structure-Activity Relationship for Thiohydantoin Androgen Receptor Antagonist for Castration-Resistant Prostate Cancer (CRPC); J. Med. Chem. 53 2779
Weight 0.1 mg
Dimensions 0.1 × 0.1 × 0.1 cm
Size:

10 mg, 50 mg

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CAS:
915087-33-1
Catalog Number:
10-3910
Activity:
Non-steroidal antiandrogen
Chemical Names:
4-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide; MDV3100
Molecular Weight:
464.44
Molecular Formula:
C21H16F4N4O2S
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White to off-white solid
Purity:
99% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Enzalutamide | Non-steroidal antiandrogen

$50.00$175.00

CAS:
915087-33-1
Catalog Number:
10-3910
Activity:
Non-steroidal antiandrogen
Chemical Names:
4-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide; MDV3100
Molecular Weight:
464.44
Molecular Formula:
C21H16F4N4O2S
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White to off-white solid
Purity:
99% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
  • 10 mg
  • 50 mg
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