Flumazenil | Benzodiazepine antagonist

Flumazenil (78755-81-4) is a benzodiazepine antagonist1, panspecific for α1, α2, α3 or α5-containing GABAA receptors2.  Reduces withdrawal sequelae in benzodiazepine dependence.3  Reverses the toxic effects, including coma and respiratory depression of zolpidem intoxication4 and gabapentin-induced coma5.

References/Citations for Flumazenil

  1. Möhler et al. (1981), Benzodiazepine antagonist Ro 15-1788; binding characteristics and interaction with drug-induced changes in dopamine turnover and cerebellar cGMP levels; Neurochem., 37 714
  2. Doble et al. (1999), New insights into the mechanism of action of hypnotics; Psychophamrcol., 13(4 Suppl. 1) S11
  3. Hood et al. (2014), Benzodiazepine dependence and its treatment with low dose flumazenil; J. Clin. Pharmacol., 77 285
  4. Lheureux et al. (1990), Zolpidem intoxication mimicking narcotic overdose: response to flumazenil; Exp. Toxicol., 9 105
  5. Masciullo et al. (2021), Flumazenil therapy for a gabapentin-induced coma: a case report; Med. Case Rep., 15 242
Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
size :

20 mg, 100 mg

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CAS:
78755-81-4
Catalog Number:
10-1081
Activity:
Benzodiazepine antagonist
Chemical Name:

8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, ethyl ester

Alternate Names:

Ro 1722;  Ro 15-1788

Molecular Weight:
303.29
Molecular Formula:
C15H14FN3O3
Solubility:
Soluble in DMSO (up to 8 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Flumazenil | Benzodiazepine antagonist

$50.00$200.00

CAS:
78755-81-4
Catalog Number:
10-1081
Activity:
Benzodiazepine antagonist
Chemical Name:

8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, ethyl ester

Alternate Names:

Ro 1722;  Ro 15-1788

Molecular Weight:
303.29
Molecular Formula:
C15H14FN3O3
Solubility:
Soluble in DMSO (up to 8 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
  • 20 mg
  • 100 mg
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