Fulvestrant | Estrogen receptor antagonist

Fulvestrant (129453-61-8) is a 17β-estradiol analog that acts as an estrogen receptor (ER) antagonist and GPR30/GPER agonist with high binding affinity.1,2 First-in-class SERD (selective ER degrader) because it inhibits ER transcriptional activity and leads to its degradation.3 Exhibits mixed neuroprotective activity in vivo.4 Clinically useful option for some advanced breast cancers.5

References:

  1. Osborne et al. (2004), Fulvestrant: an oestrogen receptor antagonist with a novel mechanism of action; Br. J. Cancer 90 (Suppl 1):S2
  2. Thomas et al. (2005), Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells; Endocrinology 146 624
  3. Wardley (2002), Fulvestrant: a review of its development, pre-clinical and clinical data; Int. J. Clin. Pract.  56 305
  4. Castro et al. (2012), Coumestrol has neuroprotective effects before and after cerebral ischemia in female rats; Brain Res. 1474 82
  5. Blackburn et al. (2018), Fulvestrant for the treatment of advanced breast cancer; Expert Rev. Anticancer Ther. 18 619
Weight 0.1 mg
Dimensions 0.1 × 0.1 × 0.1 cm
Size:

5 mg, 25 mg

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CAS:
129453-61-8
Catalog Number:
10-2541
Activity:
Estrogen receptor antagonist
Chemical Names:
7α,17β-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol; ICI- 182,780; ZD-9238
Molecular Weight:
606.77
Molecular Formula:
C32H47F5O3S
Solubility:
Soluble in DMSO (60 mg/mL); Ethanol (30 mg/mL)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Fulvestrant | Estrogen receptor antagonist

$62.00$165.00

CAS:
129453-61-8
Catalog Number:
10-2541
Activity:
Estrogen receptor antagonist
Chemical Names:
7α,17β-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol; ICI- 182,780; ZD-9238
Molecular Weight:
606.77
Molecular Formula:
C32H47F5O3S
Solubility:
Soluble in DMSO (60 mg/mL); Ethanol (30 mg/mL)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
  • 5 mg
  • 25 mg
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