Gilteritinib | FLT3 Inhibitor

Gilteritinib (1254053-43-4) is a potent inhibitor of FLT3 (IC50 = 5 nM, wild-type FLT3) with more potent activity against all FLT3 mutants.1 It also potently inhibits Axl (IC50 = 41 nM). Clinically useful in the treatment of acute myeloid leukemia. Gilteritinib has also been shown to inhibit glutamine uptake and utilization via downregulation of glutamine transporters.2

References:

  1. Lee et al. (2017) Preclinical studies of gilteritinib, a next-generation FLT3 inhibitor; Blood 129 257
  2. Thomas et al. (2021) Gilteritinib Inhibits Glutamine Uptake and Utilization in FLT-3-ITD-Positive AML; Cancer Ther. 20 2207
Weight 0.1 mg
Dimensions 0.1 × 0.1 × 0.1 cm
Size:

5 mg, 25 mg

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CAS:
1254053-43-4
Catalog Number:
10-4170
Activity:
FLT3 inhibitor
Chemical Names:
6-Ethyl-3-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide; ASP2215
Molecular Weight:
552.72
Molecular Formula:
C29H44N8O3
Solubility:
Soluble in DMSO (25 mg/ml)
Physical Properties:
Off-white to pale pink solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Gilteritinib | FLT3 Inhibitor

$70.00$250.00

CAS:
1254053-43-4
Catalog Number:
10-4170
Activity:
FLT3 inhibitor
Chemical Names:
6-Ethyl-3-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide; ASP2215
Molecular Weight:
552.72
Molecular Formula:
C29H44N8O3
Solubility:
Soluble in DMSO (25 mg/ml)
Physical Properties:
Off-white to pale pink solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
  • 5 mg
  • 25 mg
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