Gliotoxin | Immunomodulator

Gliotoxin (67-99-2) is a fungal metabolite with immunosuppressive properties; blocks phagocytosis, cytokine production and proliferation of T and B cells.1 Inhibits chymotrypsin-like activity of 20S proteasome preventing IκBα degradation and preventing NF-κB degradation2. Displays antiinflammatory activity3 and blocks leukotriene B4 production via inhibition of LTA4 hydrolase4.   It inhibits nuclear NOTCH2 and recovers a tumor-suppressor NOTCH3 activity in chronic lymphocytic leukemia cells.5

References:

  1. Waring & Beaver (1996), Gliotoxin and related epipolythiodioxopiperazines; Pharmacol., 27 1311
  2. Kroll et al. (1999), The secondary fungal metabolite gliotoxin targets proteolytic activities of the proteasome; Biol., 6 689
  3. Fitzpatrick et al. (2000), In vitro and in vivo effects of gliotoxin, a fungal metabolite: efficacy against dextran sodium sulfate-induced colitis in rats; Dis. Sci., 45 2327
  4. Konig et al. (2019), Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B4 Formation through Inhibition of Leukotriene A4 Hydrolase ; Cell Chem. Biol., 26 524
  5. Hubmann et al. (2020), Targeting Nuclear NOTCH2 by Gliotoxin Recovers a Tumor-Suppressor NOTCH3 Activity in CLL; Cells, 9 1484
Weight 0.1 mg
Dimensions 0.1 × 0.1 × 0.1 cm
Size:

1 mg, 5 mg

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CAS:
67-99-2
Catalog Number:
10-2076
Activity:
Immunomodulator
Chemical Names:

(3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epidithiopyrazino
[1,2-a]indole-1,4-dione; Aspergillin

Molecular Weight:
326.39
Molecular Formula:
C13H14N2O4S2
Solubility:
Soluble in DMSO (up to 15 mg/ml)
Physical Properties:
White lyophilized solid
Purity:
98%  HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 yeara as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Gliotoxin | Immunomodulator

$85.00$340.00

CAS:
67-99-2
Catalog Number:
10-2076
Activity:
Immunomodulator
Chemical Names:

(3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epidithiopyrazino
[1,2-a]indole-1,4-dione; Aspergillin

Molecular Weight:
326.39
Molecular Formula:
C13H14N2O4S2
Solubility:
Soluble in DMSO (up to 15 mg/ml)
Physical Properties:
White lyophilized solid
Purity:
98%  HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 yeara as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
  • 1 mg
  • 5 mg
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