GSK2982772 | RIP1 inhibitor
CAS:
1622848-92-3
Catalog Number:
10-4792
Activity:
RIP1 kinase inhibitor
Chemical Names:
(S)-5-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b]-[1,4]oxazepin-3-yl)-4H-1,2,4-traizole-3-carboxamide; GSK772
Molecular Weight:
377.40
Molecular Formula:
C20H19N5O3
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $95.00 | ||
| 25 mg | $350.00 |
GSK2982772 (1622848-92-3) is a highly selective inhibitor of Receptor-interacting Protein 1 kinase (RIP1); IC50 = 1.6 nM.1 Novel anti-inflammatory agent previously in clinical trials for psoriasis, rheumatoid arthritis, and ulcerative colitis.2,3
References:
- Harris et al. (2017), Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases; J. Med. Chem. 60 1247
- Weisel et al. (2017), Randomized clinical study of safety, pharmacokinetics, and pharmacodynamics of RIPK1 inhibitor GSK2982772 in healthy volunteers; Pharmacol. Res. Perspect. 5 e00365
- Lu et al. (2020), RIPK1 inhibitor ameliorates colitis by directly maintaining intestinal barrier homeostasis and regulating following IECs-immuno crosstalk; Biochem. Pharmacol. 172 113751
CAS:
1622848-92-3
Catalog Number:
10-4792
Activity:
RIP1 kinase inhibitor
Chemical Names:
(S)-5-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b]-[1,4]oxazepin-3-yl)-4H-1,2,4-traizole-3-carboxamide; GSK772
Molecular Weight:
377.40
Molecular Formula:
C20H19N5O3
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Safety Data Sheet:
N/A
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
GSK2982772 (1622848-92-3) is a highly selective inhibitor of Receptor-interacting Protein 1 kinase (RIP1); IC50 = 1.6 nM.1 Novel anti-inflammatory agent previously in clinical trials for psoriasis, rheumatoid arthritis, and ulcerative colitis.2,3
References:
- Harris et al. (2017), Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases; J. Med. Chem. 60 1247
- Weisel et al. (2017), Randomized clinical study of safety, pharmacokinetics, and pharmacodynamics of RIPK1 inhibitor GSK2982772 in healthy volunteers; Pharmacol. Res. Perspect. 5 e00365
- Lu et al. (2020), RIPK1 inhibitor ameliorates colitis by directly maintaining intestinal barrier homeostasis and regulating following IECs-immuno crosstalk; Biochem. Pharmacol. 172 113751
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
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