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GSK6853 | BRPF1 inhibitor

CAS:
1910124-24-1
Catalog Number:
10-4016
Activity:
BRPF1 inhibitor
Chemical Names:
N-[1,3-Dimethyl-6-[(2R)-2-methylpiperazin-1-yl]-2-oxobenzimidazol-5-yl]-2-methoxybenzamide
Molecular Weight:
409.49
Molecular Formula:
C22H27N5O3
Solubility:
Soluble in DMSO (25 mg/ml); ethanol (25 mg/ml)
Physical Properties:
White solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

GSK6853 (1910124-24-1) is a very potent (pIC50 = 8.6 vs full length protein, 7.7 in cellular assays) inhibitor of Bromodomain and PHD Finger-containing 1 (BRPF1). It displayed >1600-fold selectivity over other bromodomains.

References/Citations:

  1. Bamborough et al. (2016), GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain; ACS Med.Chem. Lett. 7 552

 

GSK6853 | BRPF1 inhibitor is also available in the Cellular Metabolism Library.
CAS:
1910124-24-1
Catalog Number:
10-4016
Activity:
BRPF1 inhibitor
Chemical Names:
N-[1,3-Dimethyl-6-[(2R)-2-methylpiperazin-1-yl]-2-oxobenzimidazol-5-yl]-2-methoxybenzamide
Molecular Weight:
409.49
Molecular Formula:
C22H27N5O3
Solubility:
Soluble in DMSO (25 mg/ml); ethanol (25 mg/ml)
Physical Properties:
White solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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