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HA-100·2HCl | Multi-kinase inhibitor

CAS:
85568-24-6
Catalog Number:
10-1609
Activity:
Multi-kinase inhibitor
Chemical Names:
5-(1-Piperazinylsulfonyl)isoquinoline dihydrochloride
Molecular Weight:
350.26
Molecular Formula:
C13H15N3O2S·2HCl
Solubility:
Soluble in DMSO (30 mg/ml); water (40 mg/ml)
Physical Properties:
White to off-white solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.
Shipping Code:
RT

HA-100·2HCl (85568-24-6) inhibits the following kinases  PKG (IC50=4 mM), PKA (IC50=8 mM), PKC (IC50=12 mM).1 Increases human fibroblast reprogramming efficiency with PD0325901, CHIR99021, A83-01 and hLIF.2 Improves single cell survival and supports high cloning efficiency in human pluripotent stem cells.3

References/Citations:

  1. Hagiwara et al. (1987), Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives; Pharmacol., 32 7
  2. Yu et al. (2011), Efficient feeder-free episomal reprogramming with small molecules; PLoS One, 6(3) e17557
  3. Chen et al. (2011), Chemically defined conditions for human iPSC derivation and culture; Nature Methods, 8 424
HA-100·2HCl | Multi-kinase inhibitor is also available in the Cellular Metabolism Library.
CAS:
85568-24-6
Catalog Number:
10-1609
Activity:
Multi-kinase inhibitor
Chemical Names:
5-(1-Piperazinylsulfonyl)isoquinoline dihydrochloride
Molecular Weight:
350.26
Molecular Formula:
C13H15N3O2S·2HCl
Solubility:
Soluble in DMSO (30 mg/ml); water (40 mg/ml)
Physical Properties:
White to off-white solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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