iJMJD6 (899548-78-8) is an inhibitor of the arginine demethylase JMJD6 (IC50 = 220 nM) with selectivity over other JmjC domain-containing proteins.1 Exhibited antiproliferative effects in HeLa (EC50 = 1.49 µM), SMCC7721 (EC50 = 9.37 µM), and MCF7 (EC50 = 9.53 µM) cells.2 Displayed no cytotoxicity towards normal cervical, liver, and breast epithelial cells. iJMJD6 significantly suppressed tumor growth in a HeLa, SMCC7721, MCF7, MDA-MB-231, U87, and HCT116 mouse xenograft models.2
References/Citations:
- Ran et al. (2019), In Silico Discovery of JMJD6 Inhibitors for Cancer Treatment; ACS Med. Chem. Lett. 10 1609
- Xiao et al. (2022), A specific JMJD6 inhibitor potently suppresses multiple types of cancers both in vitro and in vivo; Proc. Natl. Acad. Sci. USA 119 e2200753119
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