Isohelenin | NFkB inhibitor

Isohelenin (470-17-7) is a sesquiterpene lactone isolated from Mexican Indian medicinal plants known to have anti-inflammatory properties. A potent inhibitor of NFkB (complete inhibition at 5 mM)1 acting via inhibition of IKKb6. Isohelenin-mediated NFkB inhibition suppresses IL-8 expression2, iNOS expression3 and RANTES biosynthesis4. Displays protective effects in endotoxic shock in rodent models.5 Induces apoptosis in glioma cells.6

References:

  1. Bork et al. (1997), Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NK-kappaB; FEBS Lett., 402 85
  2. Mazor et al. (2000), Sesquiterpene lactones are potent inhibitors of interleukin 8 gene expression in cultured human respiratory epithelium; Cytokine, 12 239
  3. Wong and Menendez (1999), Sesquiterpene lactones inhibit inducible nitric oxide synthase gene expression in cultured rat aortic smooth muscle cells; Biophys. Res. Commun., 262 375
  4. Li et al. (2001), Induction of RANTES chemokine expression in human astrocytic cells is dependent upon activation of NK-kappaB transcription factor; Int. Mol. Med., 7 527
  5. Sheehan et al. (2002), Protective effects of isohelenin, an inhibitor of nuclear factor KappaB in endotoxic shock in rats; Endotoxin Res, 8 99
  6. Xing et al. (2019), Isoalantolactone inhibits IKKß kinase activity to interrupt the NF-kB/COX-2-mediated signaling cascade and induces apoptosis regulated by the mitochondrial translocation of cofilin in glioblastoma; Cancer Med., 8 1655
Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
Size:

5 mg, 25 mg

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CAS:
470-17-7
Catalog Number:
10-5393
Activity:
NFkB inhibitor
Chemical Name:

(3aR,8aR,9aR)-8a-Methyl-3,5-dimethylenedecahydronaphtho[2,3-b]furan-2(3H)-one

Molecular Weight:
232.32
Molecular Formula:
C15H20O2
Solubility:
Soluble in DMSO (up to 50 mg/ml) or ethanol (30 mg/ml)
Physical Properties:
White solid
Purity:
98% TLC

NMR (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Isohelenin | NFkB inhibitor

$50.00$180.00

CAS:
470-17-7
Catalog Number:
10-5393
Activity:
NFkB inhibitor
Chemical Name:

(3aR,8aR,9aR)-8a-Methyl-3,5-dimethylenedecahydronaphtho[2,3-b]furan-2(3H)-one

Molecular Weight:
232.32
Molecular Formula:
C15H20O2
Solubility:
Soluble in DMSO (up to 50 mg/ml) or ethanol (30 mg/ml)
Physical Properties:
White solid
Purity:
98% TLC

NMR (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
  • 5 mg
  • 25 mg
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