Metolazone | UPR activator and longevity inducer

Metolazone (17560-51-9) activates mitochondrial unfolded protein response (UPRMT) and -increases C. elegans lifespan.4 Clinically useful diuretic that inhibits the thiazide-sensitive Na+-Cl cotransporter (NCC) (IC50 = 0.3 µM rat), blocking sodium reabsorption.2,3  Metolazone also inhibits human carbonic anhydrase isoforms VII, XII, and XIII with nanomolar potency.4.
 

References/Citations:

  1. Ito et al. (2021), Metolazone upregulates mitochondrial chaperones and extends lifespan in Caenorhabditis elegans; Biogerontology, 22 119
  2. Beaumont et al. (1988), Thiazide diuretic drug receptors in rat kidney: identification with [3H] metolazone; Natl. Acad. Sci. USA, 85 2311
  3. Moreno et al. (2006), Affinity-defining domains in the Na-Cl cotransporter: a different location for Cl- and thiazide binding; Biol. Chem., 281 17266
  4. Temperini et al. (2008), Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct; Med. Chem. Lett., 18 2567
Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
Size:

50 mg, 250 mg

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CAS:
17560-51-9
Catalog Number:
10-5417
Activity:
UPR activator and longevity inducer
Chemical Name:

7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide

Molecular Weight:
365.83
Molecular Formula:
C16H16ClN3O3S
Solubility:
Soluble in DMSO (up to 36 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored desiccated at -20°C for up to 2 months.
Shipping Code:
RT

Metolazone | UPR activator and longevity inducer

$50.00$200.00

CAS:
17560-51-9
Catalog Number:
10-5417
Activity:
UPR activator and longevity inducer
Chemical Name:

7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide

Molecular Weight:
365.83
Molecular Formula:
C16H16ClN3O3S
Solubility:
Soluble in DMSO (up to 36 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored desiccated at -20°C for up to 2 months.
Shipping Code:
RT
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  • 250 mg
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