Metolazone | UPR activator and longevity inducer
7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide
98% by HPLC
NMR (Conforms)
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Metolazone (17560-51-9) activates mitochondrial unfolded protein response (UPRMT) and -increases C. elegans lifespan.4 Clinically useful diuretic that inhibits the thiazide-sensitive Na+-Cl– cotransporter (NCC) (IC50 = 0.3 µM rat), blocking sodium reabsorption.2,3 Metolazone also inhibits human carbonic anhydrase isoforms VII, XII, and XIII with nanomolar potency.4.
References/Citations:
- Ito et al. (2021), Metolazone upregulates mitochondrial chaperones and extends lifespan in Caenorhabditis elegans; Biogerontology, 22 119
- Beaumont et al. (1988), Thiazide diuretic drug receptors in rat kidney: identification with [3H] metolazone; Proc. Natl. Acad. Sci. USA, 85 2311
- Moreno et al. (2006), Affinity-defining domains in the Na-Cl cotransporter: a different location for Cl- and thiazide binding; J. Biol. Chem., 281 17266
- Temperini et al. (2008), Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct; Bioorg. Med. Chem. Lett., 18 2567
7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide
98% by HPLC
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Metolazone (17560-51-9) activates mitochondrial unfolded protein response (UPRMT) and -increases C. elegans lifespan.4 Clinically useful diuretic that inhibits the thiazide-sensitive Na+-Cl– cotransporter (NCC) (IC50 = 0.3 µM rat), blocking sodium reabsorption.2,3 Metolazone also inhibits human carbonic anhydrase isoforms VII, XII, and XIII with nanomolar potency.4.
References/Citations:
- Ito et al. (2021), Metolazone upregulates mitochondrial chaperones and extends lifespan in Caenorhabditis elegans; Biogerontology, 22 119
- Beaumont et al. (1988), Thiazide diuretic drug receptors in rat kidney: identification with [3H] metolazone; Proc. Natl. Acad. Sci. USA, 85 2311
- Moreno et al. (2006), Affinity-defining domains in the Na-Cl cotransporter: a different location for Cl- and thiazide binding; J. Biol. Chem., 281 17266
- Temperini et al. (2008), Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct; Bioorg. Med. Chem. Lett., 18 2567
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
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