Mito-lonidamine | Mitochondria-targeted antiglycolytic agent
Available Options
| Size | Price | Quantity | |
|---|---|---|---|
| 5mg | $100.00 | ||
| 25mg | $400.00 |
Lonidamine is an antiglycolytic drug with limited efficacy.1,2 Mito-lonidamine (2361564-49-8) is lonidamine conjugated to a triphenylphosphonium moiety via a decyl-linker which is an effective mitochondria-targeting group.3 Mito-lonidamine was shown to be 100-fold more potent than lonidamine. It is a tumor-selective inhibitor of oxidative phosphorylation inhibiting mitochondrial bioenergetics in lung cancer cells and suppressing lung cancer cell viability, growth, progression and metastasis of lung cancer xenografts in mice.3
References/Citations:
- Paggi et al. (1998), Effect of lonidamine on human malignant gliomas: biochemical studies; Neurooncol., 6 203
- Guo et al. (2016), Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine; J. Biol. Chem., 291 42
- Cheng et al. (2019), Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis; Nat. Commun., 10 2205
C43H45BrCl2N3OP
>98% TLC
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Lonidamine is an antiglycolytic drug with limited efficacy.1,2 Mito-lonidamine (2361564-49-8) is lonidamine conjugated to a triphenylphosphonium moiety via a decyl-linker which is an effective mitochondria-targeting group.3 Mito-lonidamine was shown to be 100-fold more potent than lonidamine. It is a tumor-selective inhibitor of oxidative phosphorylation inhibiting mitochondrial bioenergetics in lung cancer cells and suppressing lung cancer cell viability, growth, progression and metastasis of lung cancer xenografts in mice.3
References/Citations:
- Paggi et al. (1998), Effect of lonidamine on human malignant gliomas: biochemical studies; Neurooncol., 6 203
- Guo et al. (2016), Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine; J. Biol. Chem., 291 42
- Cheng et al. (2019), Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis; Nat. Commun., 10 2205
Related products
-
DO264 | ABHD12 inhibitor
From $70.00CAS:2301866-59-9Catalog Number:10-3712Activity:ABHD12 inhibitorChemical Name:1-(1-(3-Chloro-4-(2-chloro-4-(trifluoromethyl)phenoxy)pyridin-2-yl)piperidin-4-yl)-3-(pyridin-3-yl)thioureaMolecular Weight:542.40Molecular Formula:C23H20Cl2F3N5OSSolubility:Soluble in DMSO (up to 30 mg/ml).Physical Properties:Pale yellow solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT -
Resiniferatoxin | TRPV1 activator
From $115.00CAS:57444-62-9Catalog Number:10-2103Activity:TRPV1 activatorChemical Names:RTXMolecular Weight:628.71Molecular Formula:C37H40O9Solubility:Soluble in DMSO (65 mg/ml) or ethanol (30 mg/mL)Physical Properties:Off-white waxy solidPurity:98% HPLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.Shipping Code:RT -
Pomalidomide | Cereblon ubiquitination inhibitor
From $50.00CAS:19171-19-8Catalog Number:10-2768Activity:Cereblon ubiquination inhibitorChemical Name:1,3-Dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline; 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamideMolecular Weight:273.24Molecular Formula:C13H11N3O4Solubility:Soluble in DMSO (up to 50 mg/ml).Physical Properties:Yellow solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
Website Created by Advanta Advertising LLC.