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P7C3-A20 | NAMPT activator/Proneurogenic agent

CAS:
1235481-90-9
Catalog Number:
10-3414
Activity:
NAMPT activator/proneurogenic agent
Chemical Names:
3,6-Dibromo-ß-fluoro-N-(3-methoxyphenyl)-9H-carbazole-9-propanamine
Molecular Weight:
506.21
Molecular Formula:
C22H19Br2FN2O
Solubility:
Soluble in DMSO (40 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

P7C3-A20 (1235481-90-9) is a neuroprotective and proneurogenic agent acting via NAMPT stimulation.1 Displays neuroprotective and promotes endogenous reparative functions after traumatic brain injury (TBI).2 Furthermore it repairs the blood-brain barrier, arrests chronic neurodegeneration and restores cognition after TBI in a mouse model.3 P7C3-A20 exerts neuroprotective effects in a hypoxic-ischemic encephalopathy model.4 Suppresses neuroinflammation and protects retinal ganglion cells from optic nerve crush in a rat model.5

References/Citations:

  1. LoCoco et al. (2017), Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy; Elife, 6 e29626
  2. Blaya et al. (2014), Neuroprotective efficacy of a proneurigenic compound after traumatic brain injury; Neurotrauma, 31 476
  3. Vázquez-Rosa et al. (2020), P7C3-A20 treatment one year after TBI in mice repairs the blood-brain barrier, arrests chronic neurodegeneration, and restores cognition; Proc. Natl. Acad. Sci. USA, 117 27667
  4. Bai et al. (2020), The Small Molecule P7C3-A20 Exerts Neuroprotective Effects in a Hypoxic-ischemic Encephalopathy Model via Activation of PI3K/AKT/GSK3ß Signaling; Neuroscience, 441 197
  5. Oku et al. (2017), P7C3 Suppresses Neuroinflammation and Protects Retinal Ganglion Cells of Rats from Optic Nerve Crush; Invest. Ophthamol. Vis. Sci., 58 4877
P7C3-A20 | NAMPT activator/Proneurogenic agent is also available in the Cellular Metabolism Library.
CAS:
1235481-90-9
Catalog Number:
10-3414
Activity:
NAMPT activator/proneurogenic agent
Chemical Names:
3,6-Dibromo-ß-fluoro-N-(3-methoxyphenyl)-9H-carbazole-9-propanamine
Molecular Weight:
506.21
Molecular Formula:
C22H19Br2FN2O
Solubility:
Soluble in DMSO (40 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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