New Products
We will continue to add new products to our already extensive portfolio – check back often for the latest breakthroughs. If you can’t find what you need, contact us for information on custom synthesis.
MitoBloCK-10 (394694-98-5) is a first in class TIMM44 blocker. Translocase of inner mitochondrial membrane 44 (TIMM44) is essential for maintaining...
From $60.00
EV-96 is a cysteine-reactive immunosuppressive agent that suppresses T cell activation (EC50 <2.5 µM) via inhibition of NF-kB activation and deg...
From $90.00
E7820 (289483-69-8) is an angiogenesis inhibitor that suppresses expression of integrins α2, α3, α5, and ß1.1 Broad-spectrum antitumor and antiangi...
From $50.00
EN450 (793719-01-4) is a molecular glue that covalently interacts with a cysteine residue on the E2 ubiquitin ligase UBE2D. It displayed anti-proli...
From $80.00
SJ6986 (2765625-93-0) is a potent (IC50 = 15 nM for Cereblon; EC50 = 1.5 nM for MV4-11 AML cells), selective, and orally bioavailable molecular glu...
From $55.00
Necrostatin-34 (375835-43-1) is a selective inhibitor of RIP1 kinase. IC50s = 667 nM and 134 nM for TNFα in FAD-deficient Jurkat cells and L929 cel...
From $90.00
iPHF8 is a specific inhibitor (IC50 = 2.01 µM; EC50 = 2 µM in HeLa cells) of the human non-heme 2-oxoglutarate JmjC domain oxygenase/lysine demethy...
From $75.00
Lomitapide (182431-12-5) is a potent (IC50 = 8 nM) inhibitor of microsomal triglyceride transfer protein (MTP or MTTP) and is clinically useful in ...
From $49.00
HC-258 is a covalent inhibitor of TEAD (transcriptional enhanced associate domain), an important component of the Hippo pathway. It was able to re...
From $70.00
RECTAS (101862-47-9), a pre-mRNA splice modulator (Rectifier of Aberrant Splicing), was discovered in a small molecule screen for compounds that re...
From $70.00
JNK-IN-8 (1410880-22-6) is a potent and selective irreversible JNK inhibitor (IC50s=4.67, 18.7 and 0.98 nM for JNK1, 2 and 3 respectively).1 JNK ...
From $50.00
Gue1654 (397290-30-1) is a biased antagonist for the oxoeicosanoid receptor 1 (OXE-R, GPR170)1, the receptor for 5-Oxo-ETE, a proinflammatory eicos...
From $60.00
UNC0224 (1197196-48-7) is a potent inhibitor of histone methyltransferases G9a / EHMT2 (IC50 = 15 nM) and GLP / EHMT1 (IC50 ~ 39 nM) but not SET7/9...
From $48.00
7-Dehydrocholesterol (434-16-2) is an endogenous cholesterol precursor and is photochemically converted to vitamin D3 in the skin.1 It has recentl...
From $35.00
Cycloastragenol (84605-18-5) is a novel naturally occurring terpenoid found in Astragalus which was shown to be a telomerase activator. In CD8+ T ...
From $50.00
Migalastat (75172-81-5) is a potent, selective, and orally available inhibitor of α-galactosidase A (IC50= 40 nM).1 It binds to mutant misfolded α-...
From $40.00
ML401 (1597489-14-9) is a potent antagonist of GPR183 (IC50 = 1.03 nM), also known as EBI2 or Epstein-Barr virus-induced gene 2. ML401 inhibited ...
From $85.00
Cafestol (469-83-0) is a bioactive diterpene found in coffee.1 It displays a number of interesting protective effects including stimulation of glut...
From $75.00
Ferroptosis suppressor protein-1 (FSP1) along with ubiquinone and NAD(P)H/H+ has been identified as a second ferroptosis suppressing system which p...
From $65.00
Indisulam (165668-41-7) was originally described as a potent antitumor agent that targeted the G1 phase of cell cycle via suppression of activation...
From $65.00
