PBD-150 | Human glutaminyl cyclase inhibitor
CAS:
790663-33-1
Catalog Number:
10-4885
Activity:
Human glutaminyl cyclase inhibitor
Chemical Names:
1-(3,4-Dimethoxyphenyl)-3-93-imidazol-1-ylpropyl)thiourea
Molecular Weight:
320.41
Molecular Formula:
C15H20N4O2S
Solubility:
Soluble in DMSO (25 mg/ml) or ethanol (25 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $60.00 | ||
| 50 mg | $225.00 |
PBD-150 (790663-33-1) is an inhibitor of human glutaminyl cyclase (IC50 = 60 nM).1 PBD-150 diminished Ab plaque formation and gliosis while improving memory in a mouse model with small amounts of Ab3(pE)-40/42.2
References/Citations:
- Buchholz et al. (2006), The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship; J. Med. Chem., 49 664
- Schilling et al. (2008), Glutaminyl cyclase inhibition attenuates pyroglutamate Ab and Alzheimer’s disease-like pathology; Nat. Med., 14 1106
CAS:
790663-33-1
Catalog Number:
10-4885
Activity:
Human glutaminyl cyclase inhibitor
Chemical Names:
1-(3,4-Dimethoxyphenyl)-3-93-imidazol-1-ylpropyl)thiourea
Molecular Weight:
320.41
Molecular Formula:
C15H20N4O2S
Solubility:
Soluble in DMSO (25 mg/ml) or ethanol (25 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Safety Data Sheet:
N/A
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
PBD-150 (790663-33-1) is an inhibitor of human glutaminyl cyclase (IC50 = 60 nM).1 PBD-150 diminished Ab plaque formation and gliosis while improving memory in a mouse model with small amounts of Ab3(pE)-40/42.2
References/Citations:
- Buchholz et al. (2006), The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship; J. Med. Chem., 49 664
- Schilling et al. (2008), Glutaminyl cyclase inhibition attenuates pyroglutamate Ab and Alzheimer’s disease-like pathology; Nat. Med., 14 1106
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
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