PBD-150 | Human glutaminyl cyclase inhibitor

PBD-150 (790663-33-1) is an inhibitor of human glutaminyl cyclase (IC50 = 60 nM).1 PBD-150 diminished Ab plaque formation and gliosis while improving memory in a mouse model with small amounts of Ab3(pE)-40/42.2

  1. Buchholz et al. (2006), The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship; Med. Chem., 49 664
  2. Schilling et al. (2008), Glutaminyl cyclase inhibition attenuates pyroglutamate Ab and Alzheimer’s disease-like pathology; Med., 14 1106
Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
Size:

10 mg, 50 mg

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CAS:
790663-33-1
Catalog Number:
10-4885
Activity:
Human glutaminyl cyclase inhibitor
Chemical Names:
1-(3,4-Dimethoxyphenyl)-3-93-imidazol-1-ylpropyl)thiourea
Molecular Weight:
320.41
Molecular Formula:
C15H20N4O2S
Solubility:
Soluble in DMSO (25 mg/ml) or ethanol (25 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

PBD-150 | Human glutaminyl cyclase inhibitor

$60.00$225.00

CAS:
790663-33-1
Catalog Number:
10-4885
Activity:
Human glutaminyl cyclase inhibitor
Chemical Names:
1-(3,4-Dimethoxyphenyl)-3-93-imidazol-1-ylpropyl)thiourea
Molecular Weight:
320.41
Molecular Formula:
C15H20N4O2S
Solubility:
Soluble in DMSO (25 mg/ml) or ethanol (25 mg/ml)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
  • 10 mg
  • 50 mg
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