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SM-88 | Tyrosine metabolism inhibitor

CAS:
 30625-05-9
Catalog Number:
 10-4647

SM-88 (30625-05-9) is a “dysfunctional” tyrosine mimetic. It is taken up by cancer cells and disrupts tyrosine-mediated metabolic pathways including synthesis of the important protein mucin-1 leading to oxidative stress.1 In clinical trials with melanin, phenytoin, and sirolimus (SMK therapy) for use in advanced metastatic cancer2, in combination with methoxsalen, phenytoin, and sirolimus (MPS therapy) for prostate cancer3, and as monotherapy for metastatic pancreatic cancer4 It is also an inhibitor of tyrosine hydroxylase resulting in a reduction of catecholamines and their metabolites.5

References/Citations:

  1. Lemberg et al. (2022), Clinical development of metabolic inhibitors for oncology; J. Clin. Invest., 132 e148550
  2. Stega et al. (2020), A first-in-human study of the novel metabolism-based anti-cancer agent SM-88 in subjects with advanced metastatic cancer; Invest. New Drugs, 38 392
  3. Gartell et al. (2021), Phase II trial of SM-88, a cancer metabolism based therapy, in non-metastatic biochemical recurrent prostate cancer; Invest. New Drugs, 39 499
  4. Noel et al. (2019), Phase II trial of SM-88 in patients with metastatic pancreatic cancer: Preliminary results of the first stage J. Clin. Oncol., 37 200
  5. Brogden et al. (1981), alpha-Methyl-p-tyrosine: a review of its pharmacology and clinical use; Drugs, 21 81
SM-88 | Tyrosine metabolism inhibitor is also available in the Cellular Metabolism Library.
CAS:
30625-05-9
Catalog Number:
10-4647
Activity:
Tyrosine metabolism inhibitor
Chemical Names:
2-Amino-3-(4-hydroxyphenyl)-2-methylpropionic acid hydrochloride
Alternate Name:
Racemetyrosine HCl; DL-alpha-methyltyrosine HCl
Molecular Weight:
231.68
Molecular Formula:

C10H13NO3·HCl

Solubility:
Soluble in DMSO (at least 50 mg/ml); ethanol (at least 35 mg/ml)
Physical Properties:
Off-white solid
Purity:

>98% TLC
NMR (Conforms)

Storage Temperature:
Room temperature
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. Hygroscopic solid – protect from moisture.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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