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SR-717 | STING agonist

CAS:
2375421-09-1
Catalog Number:
10-4850
Activity:
STING agonist
Chemical Names:
Lithium 2-(6-(1H-Imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate
Molecular Weight:
381.27
Molecular Formula:
C15H8F2N5O3·Li
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month1.
Shipping Code:
RT

SR-717 (2375421-09-1) is a cell permeable and exceptionally selective STING agonist (IC50 = 7.8 µM).  It displayed robust antitumor activity in B16.F10 melanoma and MC38 colorectal adenocarcinoma mouse models. SR-717 promoted the activation of CD8+ T, natural killer, and dendritic cells as well as promoting antigen cross-priming. It was able to induce PD-L1 expression in THP1 cells and in primary human PBMC’s.

References:

  1. Chin et al. (2020), Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic; Science 369 993
SR-717 | STING agonist is also available in the Cellular Metabolism Library.
CAS:
2375421-09-1
Catalog Number:
10-4850
Activity:
STING agonist
Chemical Names:
Lithium 2-(6-(1H-Imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate
Molecular Weight:
381.27
Molecular Formula:
C15H8F2N5O3·Li
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month1.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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