Stavudine | HIV reverse transcriptase inhibitor
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 200 mg | $52.00 | ||
| 1 g | $170.00 |
Stavudine (3056-17-5) is a thymidine derivative that acts as an HIV nucleoside reverse transcriptase inhibitor (NRTI) (EC50 = 8.8 nM for HIV-1 replication in human PBMCs).1,2 Down-modulates P2X7-mediated NLRP3 inflammasome activation independent of reverse transcriptase inhibition.3 Reduces production of IL-18 and caspase-1 and stimulates Aβ-induced autophagy in macrophages.4
References/Citations:
- T-S Lin et al. (1987), Potent and selective in vitro activity of 3’-deoxythymidin-2’-ene (3’-deoxy-2’,3’-didehydrothymidine) against human immunodeficiency virus; Biochem. Pharmacol., 36 2713
- Baba et al. (1987), Both 2’,3’-dideoxythymidine and its 2’,3’-unsaturated derivative (2’,3’-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro; Biochem. Biophys. Res. Commun., 142 128
- Fowler et al. (2014), Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity; Science, 346 1000
- La Rosa et al. (2019), Stavudine Reduces NLRP3 Inflammasome Activation and Modulates Amyloid-ß Autophagy; J. Alzheimer’s Dis., 72 401
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Stavudine (3056-17-5) is a thymidine derivative that acts as an HIV nucleoside reverse transcriptase inhibitor (NRTI) (EC50 = 8.8 nM for HIV-1 replication in human PBMCs).1,2 Down-modulates P2X7-mediated NLRP3 inflammasome activation independent of reverse transcriptase inhibition.3 Reduces production of IL-18 and caspase-1 and stimulates Aβ-induced autophagy in macrophages.4
References/Citations:
- T-S Lin et al. (1987), Potent and selective in vitro activity of 3’-deoxythymidin-2’-ene (3’-deoxy-2’,3’-didehydrothymidine) against human immunodeficiency virus; Biochem. Pharmacol., 36 2713
- Baba et al. (1987), Both 2’,3’-dideoxythymidine and its 2’,3’-unsaturated derivative (2’,3’-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro; Biochem. Biophys. Res. Commun., 142 128
- Fowler et al. (2014), Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity; Science, 346 1000
- La Rosa et al. (2019), Stavudine Reduces NLRP3 Inflammasome Activation and Modulates Amyloid-ß Autophagy; J. Alzheimer’s Dis., 72 401
Related products
-
NOTUMib-1 | NOTUM inhibitor, restores Wnt signaling
From $55.00Catalog Number:10-3756Activity:NOTUM inhibitor, restores Wnt signalingChemical Name:N-(Isoquinolin-6-yl)-2-(o-tolyloxy)acetamideMolecular Weight:292.33Molecular Formula:C18H16N2O2Solubility:Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 5 mg/ml with warming).Physical Properties:Beige solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20° (des.)Stability:Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.Shipping Code:RT -
DO264 | ABHD12 inhibitor
From $70.00CAS:2301866-59-9Catalog Number:10-3712Activity:ABHD12 inhibitorChemical Name:1-(1-(3-Chloro-4-(2-chloro-4-(trifluoromethyl)phenoxy)pyridin-2-yl)piperidin-4-yl)-3-(pyridin-3-yl)thioureaMolecular Weight:542.40Molecular Formula:C23H20Cl2F3N5OSSolubility:Soluble in DMSO (up to 30 mg/ml).Physical Properties:Pale yellow solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT -
AZD7762 | Checkpoint kinase 1/2 inhibitor
From $60.00CAS:860352-01-8 (free base)Catalog Number:10-4771Activity:Checkpoint kinase 1/2 inhibitorChemical Name:3-(Carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide hydrochlorideMolecular Weight:398.88Molecular Formula:C17H19FN4O2S • HClSolubility:Soluble in DMSO (up to at least 25 mg/ml).Physical Properties:Yellow or brown solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
Website Created by Advanta Advertising LLC.