TASIN-1 | Induces Apoptosis in cells with APC truncations

TASIN-1 selectively induces apoptosis in cells with truncations in the adenomatous polyposis coli (APC) gene (but not normal cells or wild type cancer cells), an important multifunctional tumor suppressor gene.1 IC50 = 70nM for DLD1 cell line.  It inhibited cancer cell growth in human tumor xenografts (DLD1 and HT29 tumors) and a genetically engineered mouse model (CPC;Apc) of colorectal cancer.  TASIN-1 induces ER stress-dependent JNK activation with ROS production and AKT inhibition via cholesterol depletion.2

  1. Zhang et al. (2016), Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer; Transl. Med., 8 361ra140
  2. Zhang et al. (2016), Cholesterol Depletion by TASIN-1 Induces Apoptotic Cell Death through the ER Stress/ROS/JNK Signaling in Colon Cancer Cells; Cancer Ther., 17 943
Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
Size:

5 mg, 25 mg

Reviews

There are no reviews yet.

Be the first to review “TASIN-1 | Induces Apoptosis in cells with APC truncations”

Your email address will not be published. Required fields are marked *

Product Inquiry

CAS:
1678515-13-3
Catalog Number:
10-4890
Activity:
Induces apoptosis in cells with APC truncations
Chemical Names:
1-[1-(4-Methoxyphenyl)sulfonylpiperidin-4-yl]-4-methylpiperidine hydrochloride
Molecular Weight:
388.95
Molecular Formula:
C18H28N2O3S·HCl
Solubility:
Soluble in DMSO (20 mg/ml)
Physical Properties:
White to off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

TASIN-1 | Induces Apoptosis in cells with APC truncations

$70.00$275.00

CAS:
1678515-13-3
Catalog Number:
10-4890
Activity:
Induces apoptosis in cells with APC truncations
Chemical Names:
1-[1-(4-Methoxyphenyl)sulfonylpiperidin-4-yl]-4-methylpiperidine hydrochloride
Molecular Weight:
388.95
Molecular Formula:
C18H28N2O3S·HCl
Solubility:
Soluble in DMSO (20 mg/ml)
Physical Properties:
White to off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
  • 5 mg
  • 25 mg
Clear
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.