Thiolutin | Inhibitor of the DUB PSMD14

Thiolutin (87-11-6) inhibits the deubiquitinating (DUB) activity of PSMD14 exhibiting potent antitumor activity in neck squamous cell carcinoma in vitro and in vivo1.  Inhibits endothelial cell adhesion by perturbing HSP27 interactions with components of the actin and intermediate filament cytoskeleton2. Potently inhibits developmental angiogenesis in zebrafish2.  Inhibits adhesion of endothelial cells to vitronectin (IC50=0.83 μM) inhibiting tumor cell-induced angiogenesis in vivo3. Cell permeable. Active in vivo.3

References:

  1. Jing et al. (2021), Blockade of deubiquitinating enzyme PSMD14 overcomes chemoresistance in head and neck squamous cell carcinoma by antagonizing E2F1/Akt/SOX2-mediated stemness; Theranostics, 11 2655
  2. Jia et al. (2010), Thiolutin inhibits endothelial cell adhesion by perturbing Hsp27 interactions with components of the actin and intermediate filament cytoskeleton; Cell Stress Chaperones 15 165
  3. Minamiguchi et al. (2001), Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis; Int. Cancer, 93 307
Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
Size:

1 mg, 5 mg

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CAS:  87-11-6
Catalog Number:
10-2106
Activity:
Inhibitor of the DUB PSMD14
Chemical Names:
N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide;
Acetopyrrothin
Molecular Weight:
228.29
Molecular Formula:
C8H8N2O2S2
Solubility:
Soluble in DMSO (up to 15 mg/ml)
Physical Properties:
Yellow solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 3 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Thiolutin | Inhibitor of the DUB PSMD14

$60.00$186.00

CAS:  87-11-6
Catalog Number:
10-2106
Activity:
Inhibitor of the DUB PSMD14
Chemical Names:
N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide;
Acetopyrrothin
Molecular Weight:
228.29
Molecular Formula:
C8H8N2O2S2
Solubility:
Soluble in DMSO (up to 15 mg/ml)
Physical Properties:
Yellow solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 3 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
  • 1 mg
  • 5 mg
Clear
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