Torin1 | mTOR inhibitor

Torin1 (1222998-36-8) is a potent and selective ATP-competitive mTOR inhibitor, IC₅₀=2 and 10 nM for mTORC1 and mTORC2 respectively.^1,2 Active in vivo at inhibition of mTOR-mediated effects in mice (20 mg/kg).² Induces autophagy.³ Torin 1-mediated enhancement of TFEB-mediated autophagy alleviates neuronal death in oxidative stress-induced disease models.⁴ Downregulates NGF expression in RSC96 cells.⁵

References/Citations:

1. Thoreen et al. (2009), An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1; J. Biol. Chem., 284 8023
2. Liu et al. (2010), Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinoline-3-yl)benzo[h][1,6]naphthyridine-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer; J. Med. Chem., 53 7146
3. Giulitti et al. (2021), Anti-tumor Effect of Oleic Acid in Hepatocellular Carcinoma Cell Lines via Autophagy Reduction; Cell Dev. Biol., 9 629182
4. Zhuang et al. (2020), Pharmacological enhancement of TFEB-mediated autophagy alleviated neuronal death in oxidative stress-induced Parkinson’s disease models; Cell Death Dis., 11 128
5. Cheng et al. (2018), DNMT1, a Novel Regulator Mediating mTORC1/mTORC2 Pathway-induced NGF Expression in Schwann Cells; Neurochem. Res, 43 2141