Verteporfen | YAP Inhibitor

Verteporfin (129497-78-5) inhibits transcription by YAP/TAZ, IC50 = 2.5 µM, (via disruption of YAP-TEAD interaction) inhibiting autophagy and halting proliferation of cancer and cancer stem cell lines.1,2 Inhibits autophagosome formation.3 Reverses differentiation of Src-overexpressing embryonic stem cells.4 May be used to ablate unwanted neovasculature in the eye, esophageal mucosa, and elsewhere using light to create damaging free radicals.5

References/Citations for Verteporfin

  1. Saini et al. (2021), Verteporfin disrupts multiple steps of autophagy and regulates p53 to sensitize osteosarcoma cells; Cancer Cell Int., 21 52
  2. Vigneswaran et al. (2021), YAP/TAZ Transcription Coactivators Create Therapeutic Vulnerability to Verteporfin in EGFR-mutant Glioblastoma; Cancer Res., 27 1553
  3. Donohue et al. (2014), Induction of Covalently Crosslinked p62 Oligomers with Reduced Binding to Polyubiquitinated Proteins by the Autophagy Inhibitor Verteporfin; PLoS One, 9 e114964
  4. Luo et al. (2021), Src-Yap1 signaling axis controls the trophectoderm and epiblast lineage differentiation in mouse embryonic stem cells; Stem Cell Res., 54 102413
  5. Bressler et al. (2000), Photodynamic therapy with verteporfin (Visudyne): impact on ophthalmology and visual sciences; Vis. Sci., 41 624
Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
size :

5 mg, 25 mg

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CAS:
129497-78-5
Catalog Number:
10-3487
Activity:
YAP inhibitor
Chemical Name:

(4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester

Alternate Names:
CL 318952; BPD-MA
Molecular Weight:
718.79
Molecular Formula:
C41H42N4O8
Solubility:
Soluble in DMSO (up to 14 mg/ml)
Physical Properties:
Black solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Verteporfen | YAP Inhibitor

$75.00$300.00

CAS:
129497-78-5
Catalog Number:
10-3487
Activity:
YAP inhibitor
Chemical Name:

(4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester

Alternate Names:
CL 318952; BPD-MA
Molecular Weight:
718.79
Molecular Formula:
C41H42N4O8
Solubility:
Soluble in DMSO (up to 14 mg/ml)
Physical Properties:
Black solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
  • 5 mg
  • 25 mg
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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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