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Visomitin | Mitochondria-targeted antioxidant

CAS:
 934826-68-3
Catalog Number:
 10-3913

Visomitin (934826-68-3) is a mitochondria-targeted antioxidant.1,2 A useful tool for studying mitochondrial oxidative stress involvement in many disease states.3-6 In clinical trials for the treatment of various eye disorders including dry eye, glaucoma, and ocular inflammation.7,8

References/Citations:

  1. Antonenko et al. (2008), Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 1. Cationic plastoquinone derivatives: synthesis and in vitro studies; Biochemistry (Mosc)., 73 1273
  2. Antonenko et al. (2008), Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 2. Treatment of some ROS- and age-related diseases (heart arrhythmia, heart infarctions, kidney ischemia, and stroke; Biochemistry (Mosc)., 73 1288
  3. Skulachev et al. (2013), Cationic antioxidants as a powerful tool against mitochondrial oxidative stress; Biochem. Biophys. Res. Commun., 441 275
  4. Silva et al. (2016), Targeting Mitochondria in Cardiovascular Disease; Curr. Pharm. Des., 22 5698
  5. Isaev et al. (2016), Neuroprotective properties of mitochondria-targeted antioxidants of the SkQ-type; Rev. Neurosci., 27 849
  6. Tabara et al. (2014), Mitochondria-targeted therapies for acute kidney injury; Expert Rev. Mol. Med., 16 e13
  7. Brzheskiy et al. (2015), Results of a Multicenter, Randomized, Double-Masked, Placebo-Controlled Clinical Study of the Efficacy and Safety of Visomitin Eye Drops in Patients with Dry Eye Syndrome; Adv. Ther., 32 1263
  8. Wei et al. (2019), The Role of SKQ1 (Visomitin) in Inflammation and Wound Healing of the Ocular Surface; Ophthalmol. Ther., 63
Visomitin | Mitochondria-targeted antioxidant is also available in the Cellular Metabolism Library.
CAS:
934826-68-3
Catalog Number:
10-3913
Activity:
Mitochondria-targeted antioxidant
Chemical Names:
10-(4,5-Dimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyltriphenylphosphonium bromide
Alternate Name:
SKQ1
Molecular Weight:
617.61
Molecular Formula:

C36H42BrO2P

Solubility:
Soluble in DMSO (50 mg/ml)
Physical Properties:
Thick orange oil/gum. Product is very hygroscopic.
Purity:

98% TLC
NMR (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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