Modify Search
Select all
Products
Pages
Posts
Modify Search
Select all
Products
Pages
Posts

Xanomeline tartrate | M1 muscarinic agonist

CAS:
152854-19-8
Catalog Number:
10-5112
Activity:
M1 muscarinic agonist
Chemical Names:
3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridine tartrate;
LY246708 tartrate
Molecular Weight:
431.50
Molecular Formula:
C14H23N3OS
Solubility:
Soluble in DMSO (45 mg/ml) or Water (70 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or water may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Xanomeline tartrate (152854-19-8) functionally-selective M1 muscarinic receptor agonist, EC50=0.3, 92.5, 5, 52 and 42 nM for M1, M2, M3, M4 and M5 respectively.1,2 Displays positive cognitive and behavioral effects in schizophrenia and Alzheimer’s disease.3 Suppresses proinflammatory cytokine responses and improves survival in sepsis.4 Displays potent analgesic activity in rodent models of chronic inflammatory and neuropathic pain.5

References:

  1. Heinrich et al. (2009), Pharmacological Comparison of Muscarininc Ligands: Historical Versus more Recent Muscarinic M1-preferring Receptor Agonists; Eur. J. Pharmacol., 605 53
  2. Jakubik et al. (2008), Importance and prospects for design of selective muscarinic agonists; Physiol. Res., 57 Suppl. 3 S39
  3. Bender et al. (2017), Classics in Chemical Neuroscience: Xanomeline; ACS Chem. Neurosci, 8 435
  4. Rosas-Ballina et al. (2015), Xanomeline Suppresses Excessive Pro-Inflammatory Cytokine Responses Through Neural Signal-Mediated Pathways and Improves Survival in Lethal Inflammation; Brain Behav. Immun., 44 19
  5. Martino et al. (2011), The M1/M4 Preferring Agonist Xanomeline Is Analgesic in Rodent Models of Chronic Inflammatory and Neuropathic Pain via Central Site of Action; Pain, 152 2852
Xanomeline tartrate | M1 muscarinic agonist is also available in the Cellular Metabolism Library.
CAS:
152854-19-8
Catalog Number:
10-5112
Activity:
M1 muscarinic agonist
Chemical Names:
3-[4-(Hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methylpyridine tartrate;
LY246708 tartrate
Molecular Weight:
431.50
Molecular Formula:
C14H23N3OS
Solubility:
Soluble in DMSO (45 mg/ml) or Water (70 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or water may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Add to Quote

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee