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Nitazoxanide | Antiviral and antiparasitic agent / Inhibits Wnt signaling

Nitazoxanide (55981-09-4) is a clinically relevant antiparasitic agent.1It has since been repurposed as a broad-spectrum antiviral agent that is active against many RNA and DNA viruses including influenza, Hepatitis B and C, RSV, coronavirus, dengue and others.2 Its antiparasitic activity is believed to be due to inhibition of pyruvate:ferredoxin/flavodoxin oxidoreductases.3 Antiviral activity involves activation of protein kinase activated by double-stranded RNA (PKR) leading to phosphorylation of eukaryotic initiation factor 2 alpha (eIF2α).4 Nitazoxanide has also been found to inhibit Wnt signaling independent of adenomatous polyposis coli (APC) – it targets peptidyl arginine deiminase 2 (PAD2) resulting in increased citrullination of β-catenin.5

References/Citations

1) White (2004) Nitazoxanide: a new broad spectrum antiparasitic agent; Expert Rev. Anti. Infect. Ther., 2 43
2) Rossignol (2014) Nitazoxanide: a first-in-class broad-spectrum antiviral agent; Antiviral Res., 110 94
3) Hoffman et al. (2007) Antiparasitic Drug Nitazoxanide Inhibits the Pyruvate Oxidoreductases of Helicobacter pylori, Selected anaerobic Bacteria and Parasites, and Campylobacter jejuni; Antimicrob. Agents Chemother. 51 868
4) Elazar et al. (2009), The anti-hepatitis C agent nitazoxanide induces phosphorylation of eukaryotic initiation factor 2alpha via protein kinase activated by double-stranded RNA activation; Gastroenterology 137 1827
5) Qu et al. (2018), Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer; Nat. Chem. Biol. 14 94

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Catalog#  10-4633-0010

$40.00
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CAS:
55981-09-4
Catalog Number:
10-4633
Activity:
Antiviral and antiparasitic agent / Inhibits Wnt signaling
Chemical Name:
O-[N-(5-Nitrothiazol-2-yl)carbamoyl]phenyl acetate
Molecular Weight:
307.28
Molecular Formula:
C12H9N3O5S
Solubility:
Soluble in DMSO (up to at least 50 mg/ml)
Physical Properties:
Off-white solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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