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SIN-1 | Peroxynitrite Donor

CAS:
16142-27-1
Catalog Number:
10-1547
Activity:
Peroxynitrite donor
Chemical Name:
Amino-3-morpholinyl-1,2,3-oxadiazolium chloride
Alternate Name:
3-Morpholinylsydnonimine chloride
Molecular Weight:
206.63
Molecular Formula:
C6H11ClN4O2
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Water (up to 65 mg/ml)
Physical Properties:
White solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions must be prepared fresh and cannot be stored.
Shipping Code:
RT

SIN-1 (16142-27-1) is a metabolite of molsidomine1 which spontaneously releases nitric oxide and superoxide anion which react to form peroxynitrite under physiological conditions.The presence of HEPES leads to the formation of hydrogen peroxide and while its absence leads to the formation of peroxynitrite.3 Inhibits platelet aggregation.4 Inhibits aggregation and toxicity of amyloid-β in cellular assays.5

References/Citations:

1) Nishikawa et al. (1982) Inhibition of platelet aggregation and stimulation of guanylate cyclase by an antianginal agent molsidomine and its metabolites; J. Pharmacol. Exp. Ther. 220 183
2) Hogg et al. (1992) Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide; Biochem. J. 281 419
3) Kirsch et al. (1998) Hydrogen peroxide formation by reaction of peroxynitrite with HEPES and related tertiary amines. Implications for a general mechanism.; J. Biol. Chem. 273 12716
4) Priora et al. (2011) In vitro inhibition of human and rat platelets by NO donors nitrosoglutathione sodium nitroprusside and SIN-1 through activation of cGMP independent pathways; Pharmacol. Res. 64 289
5) Ren et al. (2017) Identification of a New Function of Cardiovascular Disease Drug 3-Morpholinosydnonimine Hydrochloride as an Amyloid-β Aggregation Inhibitor; ACS Omega. 2 243

SIN-1 | Peroxynitrite Donor is also available in the Cellular Metabolism Library.
CAS:
16142-27-1
Catalog Number:
10-1547
Activity:
Peroxynitrite donor
Chemical Name:
Amino-3-morpholinyl-1,2,3-oxadiazolium chloride
Alternate Name:
3-Morpholinylsydnonimine chloride
Molecular Weight:
206.63
Molecular Formula:
C6H11ClN4O2
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Water (up to 65 mg/ml)
Physical Properties:
White solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions must be prepared fresh and cannot be stored.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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