Nuclear Receptors

Nuclear receptors are ligand-gated transcription factors that regulate various physiological processes such as reproduction, inflammation, metabolism, development, and immune function. The 48 human nuclear receptors are controlled by lipophilic signaling molecules: endocrine nuclear receptors bind various steroid hormones, thyroid hormone, or the biologically active forms of vitamins A and D and retinoic acid, adopted orphan nuclear receptors bind to various lipids, metabolic intermediates, or xenobiotics, and orphan receptors have no known endogenous ligand but still operate as transcription factors. Because of their ability to directly interact with and control DNA expression, they play a significant role in cancer, diabetes, immune disorders, and other pathologies.

View All Nuclear Receptors Reagents