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Nuclear Receptors
Nuclear Receptors
Nuclear receptors are highly useful targets for drug design. The sequence-specific DNA-binding factor is responsible for many physiological events in cellular life, procreation, development and homeostasis and regulates specific genes in response to cognate ligands. Drug design using nuclear receptors is valuable in a variety of therapeutic areas.
Focus Biomolecules offers a wide range of products for epigenetic studies. Our substantial in-house development and custom synthesis capabilities make our epigenetic products one of our most popular research tools, especially in the field of cancer.
Call about customizations for your research needs: 610-994-1134.
View All Nuclear Receptors Reagents
AhR
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6-Formylindolo[3,2-b]carbazole
A very potent (Kd = 0.07 nM) endogenous ligand
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A tryptophan catabolite
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A reversible inhibitor of p53-mediated transcription and p53-dependent apoptosis
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Extends the pluripotency of hematopoietic stem cells
LXR
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Cholesterol metabolite (cholesterol 24-hydroxylase) found in the brain
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Controls cellular cholesterol homeostasis
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An LXR inverse agonist
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Interferes with fatty acid synthase
PPAR
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A highly selective and potent agonist for the peroxisome proliferator-activated receptor gamma (PPARγ)
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A selective PPARα agonist
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A selective PPARγ antagonist
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A selective and irreversible PPARδ antagonist
ROR
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Cholesterol metabolite (cholesterol 24-hydroxylase) found in the brain
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A high affinity synthetic ligand
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