Nuclear receptors
AhR Androgen CAR Coactivators Cryptochrome ER & ERR FXR Glucocorticoid LXR Mineralocorticoid PPAR Progesterone PXR RAR Rev-Erb ROR RXR VDR Other Nuclear receptors
Showing 1–12 of 67 results
-
Adipogenesis
20(S)-Hydroxycholesterol | Smoothened activator
20(S)-Hydroxycholesterol (516-72-3) is an endogenous ligand for the LXR receptor.1 It has anti-adipogenic and pro-osteogenic effects in mesenchymal...$40.00 – $90.00 Select options -
Cell Death
24(S)-Hydroxycholesterol | Endogenous cholesterol metabolite
24(S)-Hydroxycholesterol (474-73-7) is an important cholesterol metabolite (cholesterol 24-hydroxylase) found in the brain.1 It is an endogenous ag...$60.00 – $280.00 Select options -
Cholesterol
24(S),25-Epoxycholesterol | LXR agonist
24(S),25-Epoxycholesterol (77058-74-3) is a cholesterol metabolite that acts as an endogenous agonist for nuclear receptor LXR.1 Controls cellular ...$100.00 – $400.00 Select options -
Alzheimers
27-Hydroxycholesterol | Cholesterol oxidation metabolite
27-Hydroxycholesterol (20380-11-4) is a metabolite resulting from the action of sterol 27-hydroxylase on cholesterol. Concentrations of 27-hydroxyc...$40.00 – $175.00 Select options -
Atherosclerosis
5alpha,6alpha-Epoxycholesterol | LXR ligand
5α,6α-Epoxycholesterol (1250-95-9) is a naturally occurring metabolite of cholesterol. It is a major oxysterol found in processed food1 and has be...$25.00 – $85.00 Select options -
AhR
6-Formylindolo[3,2-b]carbazole (FICZ) | AhR endogenous agonist
6-Formylindolo(3,2-b)carbazole (FICZ) (172922-91-7) is a very potent (Kd = 0.07 nM) endogenous ligand for the aryl hydrocarbon receptor (AhR).1,2 ...$54.00 – $98.00 Select options -
Apoptosis
Adapalene | Retinoid RARbeta, gamma agonist
Adapalene (106685-40-9) is a stable analog of retinoic acid that acts as a selective agonist for RARβ and RARγ. Adapalene also inhibits proliferati...$30.00 – $50.00 Select options -
Differentiation
AM-580 | RARα agonist
AM-580 (102121-60-8) is a retinoic acid analog acting as a RARα agonist (Kd = 8 nM).1 Induces or blocks differentiation depending on cell type and ...$70.00 – $200.00 Select options -
New Products
AR7 | Activates chaperone mediated autophagy
AR7 (80306-38-3) is an atypical retinoid which acts as an RARα antagonist and activates chaperone-mediated autophagy (CMA) via an RAR-dependent pat...$70.00 – $280.00 Select options -
New Products
Autogramin-2 | Autophagy blocker / GRAMD1A inhibitor
Autogramin-2 (2375541-45-8) is an inhibitor of autophagy (autophagy induced by amino acid starvation IC50 = 270 nM; Rapamycin IC50 = 140 nM) acting...$70.00 – $275.00 Select options -
Adipogenesis
BADGE | PPAR gamma antagonist
BADGE (1675-54-3) is a PPARγ antagonist with μM affinity in 3T3-L1 and 3T3-F442A preadipocyte cells. Selective over PPARδ and PPARα. Antagonizes th...$30.00 – $100.00 Select options -
Alzheimers
Bexarotene | Retinoid RXR agonist
Bexarotene (153559-49-0) is a highly potent and selective retinoid X receptor (RXR) agonist (EC50=28, 25, 20 nM for RXRα, β, γ respectively).1 Clin...$40.00 – $180.00 Select options
